Our group performs research in infection in critically ill patients (namely CAP and VAP), sepsis, biomarkers and antibiotic stewardship aimed at improving diagnosis, treatment, and patient outcomes. Early detection of sepsis is crucial for effective intervention, which has driven extensive research into identifying reliable biomarkers namely CRP and PCT.
Biomarkers can provide rapid and additional diagnostic information on top on clinical judgement, facilitating timely treatment decisions. Additionally, molecular techniques like genomics, proteomics, and metabolomics are being explored to find novel biomarkers that reflect the host’s immune response and pathogen characteristics.
Our group is also interested in studying the host immune response to infection, namely resistance, tolerance, resilience and resolution.
Projects
- Severe CAP in LMIC - assess the impact of sCAP in LMIC and evaluate the need for specific areas on intervention and need for research
- Bloodstream infections in immunocompromised patients - evaluation os the impact of different immunosuppressive drugs on outcomes of BSI
- Impact of lymphopenia in outcomes of COVID19 - secondary analysis perfored in the ISARIC database to assess the impact of immune dysfunstion on clinical outcomes
Publications
- Platelet transfusion practice in the intensive care unit: the Nine-I international platelet transfusion survey.
Russell L et al
Ann Intensive Care. 2025 Jul 8;15(1):91. doi: 10.1186/s13613-025-01494-4.
- How to approach a patient hospitalized for pneumonia who is not responding to treatment?
Povoa P et al
Intensive Care Med. 2025 May;51(5):893-903. doi: 10.1007/s00134-025-07903-3. Epub 2025 May 24.
- Nosocomial lower respiratory tract infections in patients with immunosuppression: a cohort study.
Reyes LF, et al European Network for ICU-Related Respiratory Infections (ENIRRIs) European Respiratory Society-Clinical Research Collaboration Investigators.
Ann Intensive Care. 2025 May 6;15(1):61. doi: 10.1186/s13613-025-01462-y.
- A consensus of European experts on the definition of ventilator-associated pneumonia recurrences obtained by the Delphi method: the RECUVAP study.
Gaillet A et al
Intensive Care Med. 2025 Mar;51(3):506-517. doi: 10.1007/s00134-025-07856-7. Epub 2025 Mar 31.
- Association Between Type of Immunosuppression and the Incidence, Microbiology, and Outcomes of Bacterial Ventilator-Associated Lower Respiratory Tract Infections: A Retrospective Multicenter Study.
Kreitmann L et al Type of iMmunosuppression and the Incidence, Microbiology, and OutcomeS of ventilator-Associated lower respiratory tract infections (MIMOSA) Study Group.
Crit Care Med. 2025 May 1;53(5):e1080-e1094. doi: 10.1097/CCM.0000000000006615. Epub 2025 Feb 21.
- Optical coherence tomography angiography as a novel tool to assess microcirculatory dysfunction in septic shock.
Alexandre AR et al
Intensive Care Med. 2025 Mar;51(3):632-634. doi: 10.1007/s00134-025-07816-1. Epub 2025 Feb 17.
- The Digital Health Competencies in Medical Education Framework: An International Consensus Statement Based on a Delphi Study.
Car J et al
JAMA Netw Open. 2025 Jan 2;8(1):e2453131. doi: 10.1001/jamanetworkopen.2024.53131.
- Efficacy and safety of an algorithm using C-reactive protein to guide antibiotic therapy applied through a digital clinical decision support system: a study protocol for a randomised controlled clinical trial.
Rezende VMLR et al
BMJ Open. 2025 Jan 27;15(1):e084981. doi: 10.1136/bmjopen-2024-084981.
Colaborations
- Research Unit of Clinical Epidemiology, Department of Clinical Research, Odense University Hospital, Denmark
- D’Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil