Localização

CEDOC - Centro de Estudos de Doenças Crónicas NOVA Medical School / Faculdade de Ciências Médicas Universidade Nova de Lisboa Edifício CEDOC II | Rua Câmara Pestana 6 | 1150-082 | Lisboa
Telefone: 351218803100 Ext: 26022

Sílvia Vilares Conde

Docente Professor Auxiliar
Principal Investigator

Silvia V. Conde is a Professor of Pharmacology and Neuroscience at NOVA Medical School (NMS) and Principal Investigator at CEDOC (Chronic Disease Research Center) of NMS. She pursued her PhD in Pharmacology from the New University of Lisbon (Portugal) and in Biotechnology from the University of Valladolid (Spain) in 2007, on the role of purines in hypoxic signaling in the carotid body (CB).

Afterwards, she was dedicated to understanding the pathophysiological alterations in the CB and autonomic nervous system that are in the genesis of cardiometabolic and respiratory Human diseases. As a PI, she developed a new line of research on CB and dysmetabolism, based on the pioneering idea that CB controls glucose homeostasis.

She is dedicated to characterization of pathophysiological biosignals, disease signatures and fingerprints that will allow the identification of targets for therapy, particularly bioelectronic targets, as her group described that high frequency electrical stimulation of carotid sinus nerve restores glucose homeostasis in type 2 diabetes models.

Her research within this field originated 2 patents. In 2009 she was awarded with the L’Oreal Medals Honor for Women in Science Portugal and since then her group won several prizes from the Portuguese Society of Diabetes and from the Pulido Valente Foundation.

Tavares G, Martins FO, Melo BF, Matafome P, Conde SV. Dopamine, a key modulator of glucose uptake and lipid metabolism in insulin sensitive tissues in rats. 2021. Front Pharmacol. 12:713418. doi: 10.3389/fphar.2021.713418

Martins FO, Sacramento JF, Olea O, Melo BF, Prieto-Lloret J, Obeso A, Rocher A, Matafome P, Monteiro EC, Conde SV. Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue dysfunction 2021 Antioxidants 10, 1233. doi: 10.3390/antiox10081233.

Almendros I*, Basoglu OK*, Conde SV*, Liguori C, Saaresranta, T. Metabolic dysfunction in OSA: Is there something new under the sun? 2021 J Sleep Res. 21:e13418. doi: 10.1111/jsr.13418.

Tavares G, Marques D, Barra C, Rosendo-Silva D, Costa A, Rodrigues T, Gasparini P, Melo BF, Sacramento JF, Seiça R, Conde SV*, Matafome P*. Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes. 2021 Mol Metab. Apr 29:101241. doi: 10.1016/j.molmet.2021.101241.

Falvey A, Duprat F, Simon T, Hugues-Ascery S, Conde SV, Glaichenhaus N, Blancou P. Electrostimulation of the carotid sinus nerve in mice attenuates inflammation via glucocorticoid receptor on myeloid immune cells. 2020 J Neuroinflammation 17:368. DOI: 10.1186/s12974-020-02016-8.

Sacramento JF, Martins FO, Rodrigues T, Matafome P, Ribeiro MJ, Olea E, Conde SV. A2 adenosine receptors mediate whole-body insulin sensitivity in a prediabetes animal model: primary effects on skeletal muscle. 2020 Front. in Endocrinology, 11: 262. doi: 10.3389/fendo.2020.00262

Cunha-Guimaraes JP, Guarino MP, Timoteo AT, Caires I, Sacramento JF, Ribeiro MJ, Selas M, Santiago JC, Mota Carmo M, Conde SV. Carotid body chemosensitivity: early biomarker of dysmetabolism in humans. 2020 Eur. J. Endocrinol. 182: 549-557. doi: 10.1530/EJE-19-0976.

Cracchiolo M, Sacramento JF, Mazzoni A, Panarese A, Carpaneto J, Conde SV*, Micera S*. Decoding neural metabolic markers from the carotid sinus nerve in a type 2 diabetes model. 2019 IEEE Trans. Neural. Syst. Rehabil. Eng. 27: 2034-2043. doi: 10.1109/TNSRE.2019.2942398.

Sacramento JF, Olea E, Ribeiro MJ, Prieto-Lloret J, Melo BF, Gonzalez C, Martins FO, Monteiro EC, Conde SV. Contribution of adenosine and ATP to the carotid body chemosensory activity in ageing. 2019 J. Physiol. 597: 4991-5008. doi: 10.1113/JP274179

Sacramento JF*, Chew DJ*, Melo BF, Donegá M, Dopson W, Guarino MP, Robison A, Prieto-Lloret J, Patel S, Holinski BJ, Ramnarain N, Famm K, Conde SV. Bioelectronic modulation of carotid sinus nerve activity in the rat: a potential therapeutic approach for type 2 diabetes. 2018 Diabetologia. 61: 700-710. doi: 10.1007/s00125-017-4533-7.

Ribeiro MJ*, Sacramento JF*, Gallego-Martin T, Olea E, Yubero S, Melo BF, Guarino MP, Obeso A, Conde SV. High fat diet blunts the effects of leptin on ventilation and on carotid body activity. 2018 J Physiol. 596: 3187-3199. doi: 10.1113/JP275362.

Sacramento JF, Ribeiro MJ, Rodrigues T, Olea E, Melo BF, Guarino MP, Fonseca-Pinto R, Ferreira CR, Coelho J, Obeso A, Seiça R, Matafome P, Conde SV. Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver. 2017 Diabetologia. 60: 158-168. doi: 10.1007/s00125-016-4133-y.

Conde SV, Ribeiro MJ, Melo BF, Guarino MP, Sacramento JF. Insulin resistance: a new consequence of altered carotid body chemoreflex? 2017 J. Physiol. 595: 31-41. doi: 10.1113/JP271684.

Ribeiro MJ, Sacramento JF, Gonzalez C, Guarino MP, Monteiro EC, Conde SV. Carotid body denervation prevents the development of insulin resistance and hypertension induced by hypercaloric diets. 2013 Diabetes. 62: 2905-2916. doi: 10.2337/db12-1463

2021 Prémio de Investigação Alfredo da Silva: “CB meter – um novo dispositivo para a deteção o precoce da diabetes mellitus tipo 2”, Fundação Amélia de Mello, Portugal.

2021 Award Pedro Eurico Lisboa to the best paper in the Diabetes field: Carotid body chemosensitivity: early biomarker of dysmetabolism in humans. Joao P Cunha-Guimaraes et al.

2020 Eur J Endocrin 182: 549-557.

2019 Eurico Lisboa Honor Award from the Portuguese Society of Diabetes- Best publication in the Diabetes: Bioelectronic modulation of carotid sinus nerve activity in the rat: a potential therapeutic approach for type 2 diabetes. Sacramento et al.

2018 Diabetologia 61:700-710.

2017 Eurico Lisboa Award from the Portuguese Society of Diabetes- Best publication in the Diabetes field “Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver. Sacramento et al.

2017 Diabetologia. 60:158-1682016 National Diabetes Award

2016 from the Portuguese Society of Diabetes

2016 Hargreaves

2016 Award from the Portuguese Society of Diabetes/JABA RECORDATI

2012 Hargreaves

2012 Award from the Portuguese Society of Diabetes /JABA RECORDATI 2009 L’Oreal Portugal Medals of Honour for Women in Science from L’Oreal, Portuguese Science and Technology Foundation and UNESCO (to silvia conde)

2009 Nuno Castel Branco Award from the Portuguese Society of Diabetes and Lilly Portugal