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César Mendes

Docente Professor Auxiliar
Investigador Principal

Investigador Principal no laboratório Neurogenetics of Locomotion

MSc, Bioquímica, Universidade de Coimbra

Programa Doutoral Gulbenkian em Biomedicina

PhD, The Rockefeller University / ITQB NOVA

PostDoc, Columbia University Medical Center

  • M Gualdino, F Herédia, AM Medeiros, R Zanini, J Menezes, AR Mantas Dias, M Garcez, S Prag, A Jacinto, CS Mendes, A Garelli, AM Gontijo (2025) “Sex-specific control of locomotor behavior by neuronal Arhgef10 in aged Drosophila” Genetics, iyag237.
  • C Pita, IP Silva, AR Colaço, M Brotas, B Felgueiras, B Nogueira, O Carreira, AF Fonseca, M Castro, A Capucho, G Melo, FO Martins, G Ribeiro, C Calhau, S Tenreiro, H Vicente Miranda, SV Conde, CS Mendes, CN dos Santos, N Mendonça, et al. (2026) “Communicating science matters: positive evidence from the BASCOE study, a quantitative study from Brain Awareness Week outreach activities” Frontiers in Communication 11, 1721770.
  • [preprint] AF Hobbiss, MC Franco, AM Medeiros, C Rosher, CS Mendes*, MA Moita* (2024) “Covert muscle activity reveals dynamic freezing states and prepares the animal for action” bioRxiv, 2024.11. 26.622641 *equal contribution & corresponding authors
  • D Carregosa, N Loncarevic-Vasiljkovic, R Feliciano, D Moura-Louro, CS Mendes, CN dos Santos (2024) “Locomotor and gait changes in the LPS model of neuroinflammation are correlated with inflammatory cytokines in blood and brain” Journal of Inflammation 21 (1), 39
  • AM Medeiros, AF Hobbiss, G Borges, M Moita, CS Mendes (2024) “Mechanosensory bristles mediate avoidance behavior by triggering sustained local motor activity in Drosophila melanogaster” Current Biology 34 (13), 2812
  • AR Fernandes, JP Martins, ER Gomes, CS Mendes, RO Teodoro (2023) “Drosophila motor neuron boutons remodel through membrane blebbing coupled with muscle contraction” Nature Communications 14 (1), 3352
  • R Rosado-Ramos, GM Poças, D Marques, A Foito, DM Sevillano, M Lopes-da-Silva, LG Gonçalves, R Menezes, M Ottens, D Stewart, A Ibáñez de Opakua, M Zweckstetter, MC Seabra, CS Mendes, TF Outeiro, PM Domingos, CN Santos (2023) “Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage” Nature Communications 14 (1), 1918
  • AF Isidro, AM Medeiros, I Martins, D Neves-Silva (2023) “Using the MouseWalker to quantify locomotor dysfunction in a mouse model of spinal cord injury” J Vis Exp 193, e65207
  • Sardoo A, Neto A, Torres RP, Rodrigues-Manica S, Domingues L, Crespo CL, Lagoas-Gomes J, Mascarenhas V, Mendes CS, Galzerano A, Almeida SFd, Sepriano A, Ramiro S, Masi A, Nair K, Costa J, Alexandre B, Vassilevskaia T, Cunha C, Sobral D, Branco J, Gomes-Alves P, Pimentel-Santos F. (2021) “The role of muscle in the susceptibility and progression of axial Spondyloarthritis: The MyoSpA Study Protocol”, Acta Reumatol Port. Oct-Dec 2021;46(4):342-349. 
  • F Heredia, Y Volonté, J Pereirinha, M Fernandez-Acosta, AP Casimiro, CG Belém, F Viegas, K Tanaka, J Menezes, M Arana, G A. Cardoso, A Macedo, M Kotowicz, F H. Prado Spalm, MJ Dibo, RD Monfardini, TT Torres, CS Mendes, A Garelli, AM Gontijo (2021) “Innate Behavior Sequence Progression by Peptide-Mediated Interorgan Crosstalk” Nature Communications, 07 June 2021 
  • CS Mendes*, I Bartos, Z Márka, T Akay, S Márka, RS Mann*. (2015) “Quantification of gait parameters in freely walking rodents”. BMC Biology, 22 July, 13:50. * corresponding authors. 
  • MB Bouchard, V Voleti, CS Mendes, C Lacefield, WB Grueber, RS Mann, RM Bruno and EMC Hillman, (2015) “Swept Light Sheet (SLS) imaging for ultra-fast, volumetric microscopy in awake, behaving organisms”, Nature Photonics, Feb;9(2):113-119 (cover article). 
  • CS Mendes*, SV Rajendren, I Bartos, S Márka, RS Mann*. (2014) “Kinematic responses to changes in walking orientation and gravitational load in Drosophila melanogaster”, PLoS ONE 9(10): e109204. * corresponding authors.  
  • CS Mendes, I Bartos, T Akay, S Márka, RS Mann. (2013) “Quantification of gait parameters in freely walking wild type and sensory deprived Drosophila melanogaster”. eLife, January 8. 
  • “ZeroToNeuron” PTDC/BIA-BID/0681/2021, FCT Role: Participant (PI: Catarina Homem, IMM)
  • "Glamour" PTDC/BIA-COM/0151/2020, FCT Role: PI
  • “Senescent cells and their secretory phenotype: novel targets for spinal cord repair” -MC-36-2020
  • Prémio Melo e Castro 2020, Santa Casa da Misericórdia de Lisboa Role: Participant (PI: Leonor Saúde, IMM)
  • "Development of an inexpensive, simple and open-source device for SARS-Cov-2 detection." Projetos de implementação rápida para soluções inovadoras - COVID-19, FCT [ 613788604 ] Role: PI
  • “Testing the protective effect of candidate compounds in a Drosophila model of Amyotrophic Lateral Sclerosis (ALS)”, iNOVA4Health, UNL Role PI (with Claudia Santos)
  • "GEMiNI" H2020-MSCA-IF-2016, #752891 Marie Skłodowska-Curie program –Reintegration Grant-; European Commission. Role: PI Investigador FCT IF/01154/2014/CP1252/CT0003, FCT Role: PI
  • Ciência ID 601A-9F63-4964