Localização

Edifício CEDOC II, lab. 3.6 Rua Câmara Pestana, 6 1150-082 Lisboa
Telefone: 218803100 Ext: 26025

Sandra Tenreiro

Investigador  Investigador Doutorado
Principal Investigator

Investigo os mecanismos moleculares da degeneração da retina em doenças do envelhecimento no grupo Degeneração e Envelhecimento. Tenho obtido financiamento independente e participado ativamente em formação avançada. Tenho 51 publicações em revistas internacionais com revisão por pares e um H-INDEX de 28 (Scopus).

Rita Flores, Angela Carneiro, Sandra Tenreiro, Miguel C Seabra. 2021. Retinal Progression Biomarkers of Early and Intermediate Age-Related Macular Degeneration. Life. Doi: 10.3390/life12010036. Online ahead of print. Review

Flores R, Carneiro A, Serra J, Gouveia N, Pereira T, Mendes JM, Coelho PS, Tenreiro S, Seabra MC. Correlation study between drusen morphology and fundus autofluorescence. Retina. 2021 Mar 1;41(3):555-562. doi: 10.1097/IAE.0000000000002881.

Escrevente C, Falcão AS, Hall MJ, Lopes-da-Silva M, Antas P, Mesquita MM, Ferreira IS, Cardoso MH, Oliveira D, Fradinho AC, Ciossek T, Nicklin P, Futter CE, Tenreiro S, Seabra MC. Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction. Invest Ophthalmol Vis Sci. 2021 Jul 1;62(9):39. doi: 10.1167/iovs.62.9.39. https://iovs.arvojournals.org/article.aspx?articleid=2776510

Flores R, Carneiro Â, Vieira M, Tenreiro S, Seabra MC. Age-Related Macular Degeneration: Pathophysiology, Management, and Future Perspectives. Ophthalmologica. 2021 Jun 15. doi: 10.1159/000517520. https://www.karger.com/Article/FullText/517520

Ferreira C, Couceiro J, Tenreiro S, Quintas A. A biophysical perspective on the unexplored mechanisms driving Parkinson's disease by amphetamine-like stimulants. Neural Regen Res. 2021 Nov;16(11):2213-2214. doi: 10.4103/1673-5374.310675. https://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=11;spage=2213;epage=2214;aulast=Ferreira

Ferreira C, Almeida C, Tenreiro S, Quintas A. Neuroprotection or Neurotoxicity of Illicit Drugs on Parkinson's Disease. Life (Basel). 2020 Jun 11;10(6):86. doi: 10.3390/life10060086. https://www.mdpi.com/2075-1729/10/6/86

Ferreira C, Couceiro J, Família C, Jardim C, Antas P, Santos CN, Outeiro TF, Tenreiro S, Quintas A. The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism. FEMS Yeast Res. 2019 Aug 1;19(5):foz042. doi: 10.1093/femsyr/foz042. https://academic.oup.com/femsyr/article/19/5/foz042/5521208

Brás IC, Tenreiro S, Silva AM, Outeiro TF. Identification of novel protein phosphatases as modifiers of alpha-synuclein aggregation in yeast. FEMS Yeast Res. 2018 Dec 1;18(8). doi: 10.1093/femsyr/foy108.

Macedo D, Jardim C, Figueira I, Almeida AF, McDougall GJ, Stewart D, Yuste JE, Tomás-Barberán FA, Tenreiro S, Outeiro TF, Santos CN. (Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis. Sci Rep. 2018 May 3;8(1):6965. doi: 10.1038/s41598-018-25118-z. https://www.nature.com/articles/s41598-018-25118-z

Tenreiro S, Rosado-Ramos R, Gerhardt E, Favretto F, Magalhães F, Popova B, Becker S, Zweckstetter M, Braus GH, Outeiro TF. Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity. Hum Mol Genet. 2016 Jan 15;25(2):275-90. doi: 10.1093/hmg/ddv470. Epub 2015 Nov 18.

Tenreiro S, Reimão-Pinto MM, Antas P, Rino J, Wawrzycka D, Macedo D, Rosado-Ramos R, Amen T, Waiss M, Magalhães F, Gomes A, Santos CN, Kaganovich D, Outeiro TF. Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease. PLoS Genet. 2014 May 8;10(5):e1004302. doi: 10.1371/journal.pgen.1004302. eCollection 2014 May. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004302

Tenreiro S, Eckermann K, Outeiro TF. Protein phosphorylation in neurodegeneration: friend or foe? Front Mol Neurosci. 2014 May 13;7:42. doi: 10.3389/fnmol.2014.00042. eCollection 2014. https://www.frontiersin.org/articles/10.3389/fnmol.2014.00042/full

Basso E, Antas P, Marijanovic Z, Gonçalves S, Tenreiro S, Outeiro TF. PLK2 modulates α-synuclein aggregation in yeast and mammalian cells. Mol Neurobiol. 2013 Dec;48(3):854-62. doi: 10.1007/s12035-013-8473-z https://link.springer.com/article/10.1007%2Fs12035-013-8473-z

 

  • Paper Marked as Editor's Choice: The paper Ferreira et al, 2020 (https://www.mdpi.com/2075-1729/10/6/86) was handpicked by the section editor-chief, Prof. Dr. Ramón Cacabelos, from Life journal, as the best paper.
  • Top Altmetric Scoring Article and Paper Marked as Editor's Choice: The paper Ferreira et al., 2019 (https://academic.oup.com/femsyr/article/19/5/foz042/5521208) was in the top 10 highest Altmetric scores of all papers published in the FEMS Yeast Research journal in 2019.