• 2008 (on going) – Effects of EDCs in metabolic dysfunction

Our work includes the focus on EDCs as responsible for increased metabolic dysfunction in obese adult individuals and their effect on decreased metabolic improvement after bariatric surgery, as well as on EDCs effects in children and how to intervene for exposure reduction. To further understand the mechanistic basis of environmental causes of metabolic dysfunction, we conduct an integrative and multidisciplinary research approach with the inclusion of basic, clinical and population studies. This approach will help public health authorities and ultimately health professional recommendations, empowering them with new evidence-based tools grounded in a comprehensive assessment of exposure and biomarkers of effect.

Publications:
Teixeira D, Pestana D. Environmental chemical obsogens. In “Recent Advances in Obesity (1): Understanding Obesity – From its Origins to Impact on Life”. Bentham Science Publishers. 2020; 124-157
Sousa S et al. J Pharm Biomed Anal. 2020;191:113598
Ferro A et al. Arch Environ Occup Health. 2019;74(6):310-321
Sá C et al. J Agric Food Chem. 2018;66(48):12847-12854
Correia-Sá L et al. Int J Hyg Environ Health. 2018;221(3):519-530
Pestana D et al. Sci Rep. 2017;7(1):2738
Teixeira D et al. Environ Toxicol. 2016;31(11):1496-1509
Rodríguez-Alcalá LM et al. J Agric Food Chem. 2015;63(42):9341-8
Teixeira D et al. J Clin Endocrinol Metab. 2015;100(5):1792-801
Pestana D et al. Environ Res. 2014;133:170-7
Fernandes VC et al. Biomed Chromatogr. 2012;26(12):1494-501

• 2019 (on going) – IoMum cohort
  ClinicalTrials.gov Identifier: NCT04010708

Brief Summary:
Data from 2007 regarding iodine status among Portuguese pregnant women indicate this is an iodine deficient population group, with only 16.8% presenting adequate urinary iodine values. IoMum emerges from this context to monitor and update iodine status in Portuguese pregnant women and to evaluate the effectiveness of the above policy by assessing clinical compliance to iodine supplementation and the impact of iodine supplementation in this vulnerable group. IoMum will update data on iodine nutrition in Portuguese pregnant women, promoting political actions towards the elimination of iodine deficiency and thus to the reduction of nutritional, social and economic inequalities.

Publications:
Ferreira P et al. Br J Nutr. 2021:1-9. doi: 10.1017/S000711452100009X
Pinheiro C et al. Br J Nutr. 2021:1-9. doi: 10.1017/S0007114521000155

• 2015 (on going) – IoGeneration cohort
  ClinicalTrials.gov Identifier: NCT02608138

Brief Summary:
It is well known that insufficient iodine intakes impairs the production of thyroid hormones, essential for cognitive development and healthy growth.
It is estimated that one in three school age children remain iodine deficient worldwide. Whereas there is no mandatory iodisation programs in Portugal, young infants are among the most vulnerable to iodine deficiency due to their special requirements.
Therefore, this study aims to evaluate iodine status in school age Portuguese children (6-12y), compare iodine status in children, cognitive outcomes and thyroid health and monitor the use of iodised salt in school canteens exploring potential implications in children's iodine status.

Publications:
Carvalho IP et al. Intelligence. 2020 ; Vol. 82
Costa Leite J et al. Nutrients. 2017;9(5):458. doi: 10.3390/nu9050458
Mota IB et al. The iogeneration intervention study at Lisbon: Iodine status and iodised salt consumption in school-aged children. In Livro de Resumos do XVII Congresso de Nutrição e Alimentação. 2018: p. 75
Teixeira D, Calhau C, Pestana D, Vicente L, Graça P. Iodo - Importância para a saúde e o papel da alimentação. Programa Nacional para a Promoção da Alimentação Saudável, Direção-Geral da Saúde. 2014

• 2019 (on going) – IoMum cohort - Iodine status Monitoring in PortUguese pregnant woMen: impact of supplementation (with evaluation of exposure to contaminants and their association with maternal and neonatal outcomes). Investigator Initiated Study (IIS) – BIAL Portela & CA, S.A. EUR 66,5 K
• 2018 (on going) - Vitamin D and Endocrine Disruptors relationship in Breast Cancer Women//Relação entre vitamina D e desreguladores endócrinos em mulheres com cancro da mama. Investigator Initiated Study (IIS)
• 2015 (on going) – IoGeneration cohort (evaluation of exposure to contaminants and their association with children’s health outcomes). Investigator Initiated Study (IIS)
• 2017 to 2019 – IoGeneration@Lisboa. Task force with the Directorate-General of Education and the Ministry of Health
• 2015 to 2016 - IoGeneration – Iodine status in Portugal (Estado do iodo em Portugal – papel da suplementação em idades escolares). Financed by ACSS/EEA Grants; Public health initiatives program (153NU2). ~EUR 434 K
• 2010 to 2012 - Metabolic impact of bariatric surgery. Foundation for Science and Technology (FCT; HMSP-ICJ/SAU-ICT/0007/2009). EUR 100 K Clinical trials ID: • ClinicalTrials.gov ID: NCT04010708 - Iodine Status Monitoring in PortUguese Pregnant woMen: Impact of Supplementation (IOMUM). • ClinicalTrials.gov ID: NCT02608138 - Iodine Status in Portuguese Children and the Role of Salt Fortification in School Canteens (IoGeneration)
• 2008 (on going) – Effects of EDCs in metabolic dysfunction. Foundation for Science and Technology (FCT; SFRH/BD/46640/2008, SFRH/BD/78367/2011, SFRH/BD/64691/2009, SFRH/BD/46640/2008)

Clinical trials ID:

• ClinicalTrials.gov ID: NCT02608138 - Iodine Status in Portuguese Children and the Role of Salt Fortification in School Canteens (IoGeneration)
• ClinicalTrials.gov ID: NCT04010708 - Iodine Status Monitoring in PortUguese Pregnant woMen: Impact of Supplementation (IOMUM).

• A review of exposure assessment methods for epidemiological studies of health effects related to industrially contaminated sites
• Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p’-DDE
• Linhas de orientação sobre contaminantes de alimentos
• Inflammatory and Cardiometabolic Risk on Obesity: Role of Environmental Xenoestrogens

Teixeira D, Pestana D. Environmental chemical obsogens. In “Recent Advances in Obesity (1): Understanding Obesity – From its Origins to Impact on Life”. Bentham Science Publishers. 2020; 124-157

Sousa S et al. J Pharm Biomed Anal. 2020;191:113598

Maia ML et al. Heliyon. 2020;6(9):e04870

Hoek G et al. Epidemiol Prev. 2018;42(5-6S1):21-36

Ferro A et al. Arch Environ Occup Health. 2019;74(6):310-321

Sá C et al. J Agric Food Chem. 2018;66(48):12847-12854

Castro-Correia C et al. Environ Sci Pollut Res Int. 2018;25(18):17915-17919

Correia-Sá L et al. Int J Hyg Environ Health. 2018;221(3):519-530

Correia-Sá L et al. Environ Sci Pollut Res Int. 2017;24(35):27502-27514.

Correia-Sá L et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2018;1072:9-16

Pestana D et al. Sci Rep. 2017;7(1):2738

Correia-Sá L et al. Environ Int. 2017;102:79-86

Lessmann F et al. Environ Int. 2017;104:25-32

Norberto S et al. J Cell Biochem. 2017;118(2):366-375

Teixeira D et al. Environ Toxicol. 2016;31(11):1496-1509

Rodríguez-Alcalá LM et al. J Agric Food Chem. 2015;63(42):9341-8

Teixeira D et al. J Clin Endocrinol Metab. 2015;100(5):1792-801

Pestana D et al. Environ Res. 2014;133:170-7

Teixeira D, Pestana D, Calhau C, Graça P. Linhas de orientação sobre contaminantes de alimentos. Programa Nacional para a Promoção da Alimentação Saudável, Direção-Geral da Saúde. 2014

Pestana D et al. Environ Toxicol. 2015;30(2):168-76

Correia-Sá L et al. J Sep Sci. 2012;35(12):1521-30

Fernandes VC et al. Biomed Chromatogr. 2012;26(12):1494-501

• 2014 - Pestana D, ECO2014 Prémio de Melhor Poster (Nutrição, Comportamento, Atividade e Meio Ambiente) e Bolsa de Viagem, 21º Congresso Europeu de Obesidade, Sofia, Bulgária Obes Facts.
  2014 May; 7(Suppl 1): 1–187. » T2:PO.004 “Adipose tissue impairment as a central dysmetabolism inducing effect triggered by persistent organic pollutants”

• Prof.ªs Cristina Matos, Valentina Domingues and Virgínia Fernandes, Chemistry department, REQUIMTE/LAQV – Instituto Superior de Engenharia do Porto (ISEP), Portugal;
• Prof. Leonardo Trasande, Director of the Division of Environmental Pediatrics and Vice Chair for Research in the Department of Pediatrics at New York University (NYU) School of Medicine, USA 
• Prof. Miguel Constância, Department of Obstetrics and Gynaecology, University of Cambridge, UK; 
• Prof. Cátia Martins, Institute for Cancer Research and Molecular Medicine, Faculdade de Medicina, Trondheim, Noruega; • Prof. Anne Bouloumié, INSERM, Toulouse, France;
• Prof. Rosário Monteiro, Department of Community Medicine, Information and Decision in Health, FMUP, CINTESIS, Portugal;
• Prof.ª Elisa Keating, Faculty of Medicine, University of Porto (FMUP), Principal Investigator of the ProNutri research group of CINTESIS;
• Prof. Luís Filipe Azevedo, Faculty of Medicine, University of Porto (FMUP), Principal Investigator and Lead of the Research Group EvidenS&HTA at CINTESIS and Coordinator of the TL 4 - Healthcare Policy, Technology and Digital Transformation, of the Associate Laboratory RISE;
• Prof. João Leite, Universidade Fernando Pessoa (UFP) and a researcher at CINTESIS/FMUP;
• Prof. Agostinho Almeida and Edgar Pinto, REQUIMTE/LAQV - Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal;
• Prof.ª Cíntia Castro-Correia, Faculty of Medicine, University of Porto (FMUP), Pediatrician and pediatric endocrinologista, and a researcher at CINTESIS/FMUP; 
• Prof. Rui Coelho and Prof.ªs Isabel Brandão and Irene Palmares, Departamento de Neurociências e Saúde Mental, FMUP, Portugal; 
• Prof. António Taveira Gomes, Departamento de Cirurgia, FMUP, Portugal;
• Prof.ªs Ana Cristina Santos and Sofia Vilela, ISPUP, Instituto de Saúde Pública da Universidade do Porto, Portugal;
• Prof. Jorge Lima, NMS|FCM, UNL & CUF Descobertas Hospital - Coordinator of Obstetrics, Gynecology and Obstetrics Service, Portugal;
• Dr. Miguel Vasques, The Howard Hughes Medical Institute (HHMI) and Obesity Laboratory, Instituto Gulbenkian de Ciência, Oeiras, Portugal e Serviço de Encrinologia do Hospital Curry Cabral, Centro Hospitalar Universitário Lisboa Central, Portugal;
• Dra Ana Correia, Unidade da Mama, Hospital São José, Centro Hospitalar Universitário Lisboa Central, Portugal;
• Dra Marta Duarte, Unidade de Cirurgia Plástica e Reconstrutiva, Hospital São José, Centro Hospitalar Universitário Lisboa Central, Portugal.