Location

NOVA Medical School - Grey Building | Rua Câmara Pestana nº 6, 1150-082, Lisboa, Portugal

Helena Soares

Investigador  Investigador Principal
Principal Investigator

Helena Soares leads a multidisciplinary team integrating medical doctors and biomedical researchers. She obtained a Pharmacy degree from the University of Coimbra (2001), completed a PhD in Immune Physiology at The Rockefeller University (2006) with a Gulbenkian Fellowship, and undertook postdoctoral training at the Institut Pasteur supported by a Long-Term EMBO Fellowship.

In 2014, she returned to Portugal through the highly competitive FCT Investigator Programme and established her independent laboratory at NMS in 2015. She currently serves as Executive Board Member and Thematic Line Coordinator of the iNOVA4Health Research Unit (2025–2029), which secured €9.5M in institutional funding. She has obtained competitive funding from FCT, ESCMID, Gilead, and Pfizer, and as team member in Horizon Europe programmes (EVCA and MPS Twinnings).

Her research focuses on how tissue microenvironments regulate human immune responses and how biological and environmental variables, sex, age, temperature, and pollutants, shape immunity in health and disease. Her programme bridges fundamental and clinical research through collaborations with 10 hospitals. She maintains strong industry partnerships (Pfizer, Gilead, Medinfar, Janssen, Sanofi), including consultancy for Merck Sharp & Dohme on vaccine literacy.

She coordinates postgraduate education in vaccine hesitancy and sex-differential health, teaches immunology at undergraduate and postgraduate levels, delivers invited international lectures, and is active in science communication (>30 media contributions). She currently sits on the Fiscal Board of the Portuguese Society for Immunology.

Internationally, she provides scientific leadership as co-coordinator of the EFIS Study Group on Immune Sex Differences and expert collaborator of the European Commission JRC CIAO project. 

  • Marcus Altfeld, Camila Consiglio, Darragh Duffy, Molly Ingersoll, Cliona O'Farrelly, Tal Pecht, Tal Shay, Helena Soares. The essential integration of sex and gender in immunological research. Immunology Letters 2025. DOI: 10.1016/j.imlet.2025.107097
  • José Feliz, Juliana Gonçalves, Carolina Cabedo, Maria Gamas, Maria Inês Neves, Helena SoaresLong-term sex differences in symptoms and immune profile in Long COVID. Preprint: Research Square 2025. DOI: 10.21203/rs.3.rs-7642874/v1
  • Gonçalves J, Melro M, Alenquer M, Araújo C, Castro-Neves J, Charepe N, Serrano F, Pontinha C, Amorim MJ, Soares H. Balance between maternal antiviral response and placental transfer of protection in gestational SARS-CoV-2 infection. JCI Insight 2023. 8(17):e167140, DOI: 10.1172/jci.insight.167140.
  • Gonçalves J, Juliano AM, Charepe N, Alenquer M, Athayde D, Ferreira F, Archer M, Amorim MJ, Serrano F, Soares H. Secretory IgA and T cells targeting SARS-CoV-2 spike protein are transferred to the breastmilk upon mRNA vaccination. Cell Rep Med 2021. 2. DOI: 10.1016/j.xcrm.2021.100468.
  • Amaral-Silva D, Gonçalves R, Torrão RC, Torres R, Pimentel-Santos F, Mourão AF, Costa M, Falcão S, Araújo MP, Gonçalves MJ, Lopes C, Neto A, Marona J, Costa T, Costa W, Branco JC, Soares H. Direct tissue sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients. Communications Biology 2021. 4:1135. DOI:10.1038/S42003-021-02659-0  
  • Charepe N, Gonçalves J, Juliano AM, Lopes DG, Canhão H, Soares H, Serrano F. COVID-19 mRNA vaccine and antibody response in lactating women: a prospective cohort study, BMC Pregnancy and Childbirth 2021. 632. DOI: 10.1186/s12884-021-04051-6
  • Alenquer M, Ferreira F, Lousa D, Valério M, Medina-Lopes M, Bergman M-L, Gonçalves J, Demengeot J, Leite RB, Lilue J, Ning Z, Penha-Gonçalves C, Soares H, Soares CM, Amorim MJ. Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies. PLOS Pathogens 2021. 17(8): e1009772. DOI: 10.1371/journal.ppar.1009772
  • Santos-Pereira A, Triunfante V, Araújo PMM, Martins J, Soares H, Poveda E, Souto B, Osório NS. Nationwide Study of Drug Resistance Mutations in HIV-1 Infected Individuals under Antiretroviral Therapy in Brazil. Int. J. Mol. Sci. 2021. 22(10), 5304. DOI:10.3390/ijms22105304
  • Gonçalves J, Sousa RL, Jacinto MJ, Amaral-Silva D, Paula F, Sousa R, Zahedi S, Carvalho J, Cabral MG, Costa M, Branco JC, Canhão H, Alves JD, Rodrigues A, Soares H. Evaluating SARS-CoV-2 Seroconversion Following Relieve of Confinement Measures. Front Med 2020. DOI: 10.3389/fmed.2020.603996
  • Silva JG, Martins NP, Henriques R, Soares H. HIV-1 Nef Impairs the Formation of Calcium Membrane Territories Controlling the Signaling Nanoarchitecture at the Immunological Synapse. J. Immunol. 2016. 197: 4042 Highlighted in J Immunol November 15, 2016, 197 (10) 3749-3750. DOI:
  • 2023 | Best European Campaign Award granted conjointly by the International Union of Immunological Societies (IUIS) and by the European Federation of Immunological Societies (EFIS) to the vaccination campaign undertaken in 2021: “Conversations with Scientists: Decades of Research for Days of (COVID-19) Vaccines” Role; Core Organizer and Scientific Curator
  • 2021- 27 | Scientific Employment FCT work contract (Assistant Professor Level), Portuguese Foundation for Science and Technology
  • 2020-21 | Principal Investigator (Assistant Professor Level), CHRC, Portugal
  • 2019-20 | Principal Investigator (Assistant Professor Level), The Discoveries Centre for Regenerative and Precision Medicine, Portugal
  • 2014-19 | Investigador FCT research contract, Portuguese Foundation for Science and Technology
  • 2011-14 | French AIDS Association (Sidaction) & AIDS Research Foundation (ANRS) postdoctoral fellowships
  • 2008-10 | European Molecular Biology Organization (EMBO) postdoctoral fellowship