Theses and Dissertations

DOCTORAL THESES

Medicine

• ALMEIDA, Ana - Screening for retinopathy of prematury: how can we do better?
• BRANCO, Patrícia - Peritoneal histomorphology, biomarkers and clinical outcomes in patients with chronic kidney disease on peritoneal dialysis
• BRITO, Maria - Cervical squamous cell carcinoma (SCC) and cervical intraepithelial lesions (SILS) in hiv women: contribution of the local immune response (2 years embargo - 20.10.2023 to 20.10.2025)
• COUTO, Nuno - Tumoral exosomes profile in metastatic pancreatic adenocarcinoma patients during chemotherapy treatment
• FERNANDES, João - Social cognition in patients with schizophrenia and autism spectrum disorder
• FERREIRA, Alexandre - Improving the quality of colonoscopy
• GOUVEIA, Catarina - Osteoarticular infections in pediatric patients : changes in epidemiology and treatment (2 years embargo - 22.06.2023 to 22.06.2025)
• LUZ, José - BestFLR. Randomized controlled clinical trial comparing preoperative portal embolization with polyvinyl alcohol particles (PVA) and coils versus N-butyl cyanoacrylate (NBCA)
• MARIA, Ana - Accounting for doctors and patients perceptions in telehealth services implementation
• PARREIRA, Leonor - A novel simplified approach to radiofrequency catheter ablation of idiopathic ventricular outflow tract premature ventricular contractions: from substrate analysis to results
• RAPOSO, Luís - Intracoronary transfer of human Umbilical Cord matrix‐derived Mesenchymal Stem Cells for the preservation of left ventricular function after acute myocardial infarction: assessment of invasive hemodynamic effects and potential underlying mechanisms in a large animal pre-clinical model (1 year embargo - 02.06.2023 to 02.06.2024)
• REIS, Teresa - Prescription of benzodiazepines by primary health care doctors: characteristics of prescribing trend and implementation of an online program (2 years embargo -24.02.2023 to 24.02.2025)
• TELES, Rui - Transcatheter aortic valve implantation (TAVI) a reference model in percutaneous cardiovascular intervention

Biomedicine

• BOTA, Catarina - Testing the role of asymmetric migratory behaviors found in a novel population of mesendodermal cells (2 years embargo - 30.10.2023 to 30.10.2025)
• BURRINHA, Tatiana - Lysosome dysfunction, the link between aging and alzheimer’s disease? (3 years embargo - 27.01.2023 to 27.01.2026)
• COTOVIO, Gonçalo - Interhemispheric imbalance in mood disorders (3 years embargo - 24.01.2023 to 24.01.2026)
• CORREIA, Maria - Hydroxytyrosol and hypertension associated with chronic intermittent hypoxia: impact and contribution of AhR alternative pathway (embargo)
• DELGADO, Raquel - Regulation of survival and death pathways in chronic lymphocytic leukemia (3 years embargo - 28.06.2023 to 28.06.2026)
• FIALHO, Isabel - A psicoterapia de grupo de orientação grupanalítica: levantamento e caraterização a nível nacional, em meio hospitalar, e avaliação da eficácia em grupos psicoterapêuticos de diferentes dimensões
• QUADRADO, Carolina - Nutrient postingestive signalling : the asymmetry of the response of dopaminergic neuronal circuits (3 years embargo - 09.03.2023 to 09.03.2026)
• MADEIRA, Natália - Rethinking memory acquisition: the rules of Memory cooperation and competition (3 years embargo - 31.05.2023 to 31.05.2026)
• SOUSA, Daniela - Human Papillomaviruses in Head and Neck Squamous cell carcinomas: the relevance of HPV16 variants

Health Sciences - Biomedicine

• BRANDÃO, Duarte - A cell-type specific selection system for stem cell therapy (and other) purposes (3 years embargo - 30.05.2023 to 30.05.2026)
• FERREIRA, Andreia - Modulating membrane traffic regulators to impair breast cancer progression (3 years embargo - 13.03.2023 to 13.03.2026)

Regenerativa Medicine (ProRegeM)

• CASTANHEIRA, Pedro - The role of rab11a and rab11b in breast cancer progression (3 years embargo - 20.04.2023 to 20.04.2026)
• LOPES, João - The role of Cerl2 in cardiomyocyte differentiation and heart regeneration (3 years embargo - 11.04.2023 to 11.04.2026)
• MEYER, Catarina - The mechanism of LAMP2A-mediated exosome biogenesis and their role in intercellular communication
• MIRFAKHAR, Farzaneh - Investigating the association of endocytic trafficking regulator CD2AP gene variant K633R and the risk of developing Alzheimer's disease (3 years embargo - 01.02.2023 to 01.02.2026)
• PESTANA, Sara - Testing the role of extracellular vesicles in early left right patterning

Aging and Chronic Diseases

• KUBASOVA, Nadiya - Epigenetics and genetics of hematopoietic stem cells heterogeneity
• NETO, Matilde - Molecular mechanisms of melanin internalization and processing in keratinocytes(3 years embargo - 29.06.2023 to 29.06.2026)
• RODRIGUES, Joana - Dissecting the role of ral gtpase in neuronal and glial structure and function
• SILVA, Daniela - The role of toll-like receptors expressing t cells in autoimmunity (3 years embargo - 05.04.2023 to 05.04.2026)

MASTER DISSERTATIONS

Biochemistry for Health

• BARRADAS, Bárbara - Protein Glycosylation in Cancer Drug Resistance (3 years embargo - 15.03.2023 to 15.03.2026)
• CAÇÃO, Marta - Evaluating the protective effect of beries-derived poliphenol metabolites in mouse retina degeneration (3 years embargo - 27.03.2023 to 27.03.2026)
• CHANDE, Andreia - Alternative splicing variants in breast cancer
• CRISPIM, Daniel - The role of the cytochrome P450-enzyme complex protein factors and other oxidoreductases in the mechanisnms of acquired cancer drug resistance (2 years embargo)
• FRANCISCO, Mafalda - Phenylalanine hydroxylase (pah) enzymosomes: development of a nanosystem for enzyme substitution/replacement therapies (2 years embargo - 04.04.2023 a 04.04.2025)
• PEDRO, Margarida - Development of a screening pipeline to identify modulators of NRF2 activity (3 years embargo)
• RAMOS, Carolina - The role of extracellular vesicles in chemotherapy resistance mediated by the breast cancer-liver axis (2 years embargo)
• SALVADO, Beatriz - Beating primary ciliary dyskinesia (2 years embargo)
• SESIFREDO, Isabel - Role of lysosome exocytosis in breast cancer progression (3 years embargo)
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Clinical Research Management (MEGIC)

• AFONSO, Catarina - Coordenação de ensaios clínicos no Hospital da Luz Learning Health: relatório de estágio curricular
• COSTA, Carlota - Gestão do centro de investigação: promoção e organização de investigação interna
• EÇA, Rita - Digitalização de um centro de investigação clínica: desenho de um plano estratégico trabalho de projeto / Rita Horta Osório da Cunha de Eça 
• PICADO, Mariana - A fadiga em doentes com cancro do pulmão sob imunoterapia FADIMUN: estudo observacional prospetivo (1 year embargo)

NOVA Biomedical Research (NBR)

• ALVES, Beatriz - VIP neuroepithelial circuit in immunity and metabolism (3 years embargo)
• COELHO, Pedro - Self-paced VS cued movement initiation : characterising behaviour and underlying neural circuits (embargo)
• DAMIÃO, Catarina - Exploring neuron-glia interaction in Drosophila and human¬derived neuropsheroids
• FERRAZ, Luís - Exosomes in transcellular proteostasis and Age-Related Macular Degeneration
• FERREIRA, Bárbara - The role of glucagon : GCGR axis in pancreatic neuroendocrine
• GRENHAS, Maria - Comparative analysis of size-exclusion chromatography and ultracentrifugation for efficient isolation of extracellular vesicles in Multiple Myeloma (embargo)
• JUSTO, Inês - Exploring the role of the ESCRT-111 proteins in response to telomeric replication stress in ALT cancer cells (embargo)
• LAGOA, Filipa - The role of the immune system in MuSC aging during regeneration (embargo)
• LEÃO, José - Modulation of adenosinergic system as a therapeutic target for dysmetabolism  
• OLIVEIRA, Inês - Screening innate immunotherapy strategies in zebrafish xenograft models
• PACHECO, Maria - Developing 3D in vitro models of basal cell carcinoma (embargo)
• PEREIRA, Pedro - Extracellular vesicles : communication agents in prediabetes (1 year embargo)
• PINHO, Mariana - Dissection of glial contributions to neuronal structure and function in Drosophila melanogaster? (3 years embargo)
• QUADRADO, Carolina - Nutrient postingestive signalling: the asymmetry of the response of dopaminergic neuronal circuits
• REIS, Fábio - Epithelial to mesenchymal transition pathway in pituitary endocrine tumours
• ROSADO, Pedro - Study of the impact of the IL-7R on non-small cell lung cancer (embargo)
• SALDANHA, Inês - Extracellular Vesicles as biomarkers of hepatic metastasis in pancreatic cancer patients (embargo)

Human Nutrition and Metabolism

• BAETA, Inês - Catering for athletes: food and nutritional considerations at international athletics championships (3 years embargo - 08.11.2023 to 08.11.2026)
• CALAFATE, Catarina - Evaluation of mental health, cognitive function and quality of life of breast cancer patients and the link with gut microbiota : a preliminary study
• CAMPOS, Teresa - The link between breast cancer treatment toxicity and gut microbiota: a preliminary study (3 years embargo - 17.07.2023 to 17.07.2026)
• CAPITÃO, Carolina - The relationship between tumor metabolic activity and body composition changes in patients with cancer (3 years embargo)
• CARREIRA, Eduarda - The effects of a Mediterranean-style diet in heart disease patients running a cardiac rehabilitation program (3 years embargo - 29.11.2023 to 29.11.2026)
• FIGUEIRA, Carina - Effects of a weight loss program on cardiovascular risk in adults with obesity: the WLM3P study 
• FONSECA, Gisela - Efeito metabólico de um pequeno-almoço rápido e nutricionalmente equilibrado, desenvolvido para colmatar as necessidades da geração Y : estudo clínico aleatorizado e cruzado (1 year embargo)
• FREITAS, Mariana - O efeito de uma dieta anti-inflamatória na atividade da doença e na qualidade de vida de pacientes com artrite reumatóide: ensaio clínico randomizado controlado paralelo (1 year embargo)
• GAMA, Maria - Impact on diet quality and dietary burden of sapropterin dihydrochloride use in children with phenylketonuria : a 6 months follow-up report (embargo)
• HASSAN, Mihabd - Role of the level of micronutrients (iron, zinc and vitamin D) in developing febrile convulsion in children under six years old (3 years embargo)
• HENRIQUES, Beatriz - Impacto da ingestão de uma infusão de funcho pelas mães na cólica infantil em bebés amamentados com leite materno (2 years embargo)
• LEMOS, Maria - Urinary biomarkers of biofortified beef in healthy women explored by untargeted metabolomics
• MONTEIRO, Ana - Multiple element exposure in a population of school-aged portuguese children : from health outcomes to preventive tools (2 years embargo)
• OLIVEIRA, Sofia - Assessment of exposure to plastic aditives flame retardants in portuguese pregnant women: the role of dietary consumption and associated health effects (embargo 30.11.2023 to 30.11.2025)
• PERES, Maria - Biochemical and anthropometric outcomes of patients with paediatric heterozygous familial hypercholesterolemia after COVID-19 pandemic lockdowns (embargo 3 anos)
• PISCO, Alexandra - Effects of a weight loss program on body composition in adults with obesiy: the WLM3P study
• RELVA, Bárbara - Caracterização das alterações metabólicas que ocorrem durante uma dieta hipocalórica de 8 semanas e a sua relação com a eficiência da perda de peso
• RIBEIRO, Laila - Avaliação da exposição in utero a contaminantes ambientais em recém-nascidos prematuros (1 year embargo - 09.01.2023 to 09.01.2024)
• RODRIGUES, Diana - Microspa – gut microbiota and axial spondyloarthritis: the impact on anti-tnf therapy
• SILVA, Rita - BIOMEQUIZ: validation of a food questionnaire to select stool donors (3 years embargo - 13.07.2023 to 13.07.2026)
• SOUSA, Catarina - Avaliação da exposição gestacional a metais pesados e a sua associação com o estado de saúde da mulher grávida & outcomes à nascença (2 years embargo - 22.09.2023 to 22.09.2025)
• VEIGA, Sofia - Levels of essential and toxic metals in adults with obesity undergoing a weight loss intervention: is there a link with meta-inflammation? (1 year embargo - 21.07.2023 to 21.07.2024)
• VIDINHA, Duarte - The effects of a school-based intervention on the dietary quality of mid-morning snacks in second grade Azorean children (1 year embargo - 24.07.2023 to 24.07.2024)

Primary Care Mental Health

• DUTRA, Filipa - Parenting styles in victims of bullying in childhood and adolescence
• RAMOS, Laura - PTSD occurrence and management strategies during the COVID-19 pandemic

DOCTORAL THESES

Medicine - Clinical Research

ALMEIDA, Ana - Screening for retinopathy of prematury: how can we do better? (2 years embargo - 04.02.2022 to 04.02.2024)

BALSINHA, Maria - Users and health professionals' perspectives regarding Portuguese primary care services: a focus on dementia (1 year embargo - 21.03.2022 to 21.03.2023)

COELHO, Ana - Renal recovery after an episode of acute kidney injury

FERREIRA, Ana - Bone-derived hormones, bone disorders and cardiovascular disease in kidney transplanted patients

FERREIRA, Bruna - The role of extracellular vesiclesin multiple myeloma

MARTO, Natália - In vivo phenotyping of sultia enzymes in man implications for precision medicine

MENDES, Neuza - Hemoglobina a1c, frutosamina e albumina glicada na diabetes gestacional: marcadores de controlo metabólico e desfechos materno-fetais

NEVES, Marisa - The role of high-density lipoproteins in the activation of T lymphocytes and regulation of immune response

OURÔ, Susana - Biological and surgical determinants in the treatment of rectal cancer 

ROSA, Sílvia - Microcirculation dysfunction in hypertrophic cardiomyopathy

SILVA, Tiago - Circulating micro-rna profiles according to atherosclerotic disease expression : a contribute to phenotype characterization and insights into pathophysiology

Medicine - Biomedicine

BORBINHA, Jorge - The effects of metabolic reprogramming during zebrafish tissue regeneration (3 years embargo - 07.12.2022 a 07.12.2025)

LOPES, Liliana - Molecular mechanisms of melanin secretion by melanocytes and processing within keratinocytes (3 years embargo - 21.12.2022 a 21.12.2025)

MATIAS, Ana - Dissecting the differential molecular signature in patients From african-origin with triple-negative breast cancer (2 years embargo - 28.04.2022 a 28.04.2024)

SOUSA, Marcelo - Substantia Nigra in Parkinson’s disease: exploring the encoding of movement kinematics by Dopaminergic Neurons (2 years embargo - 25.02.2022 to 25.02.2024)

Mecanismos de Doença e Medicina Regenerativa

MARQUES, Graça - Characterization of novel factors regulating neural stem cell proliferation, temporal fate and neuronal diversity (3 years embargo - 29.04.2022 to 29.04.2025)

MONTEIRO, Ana - Underlying role of glycation in the pathogenesis of Parkinson’s disease (3 years embargo - 30.11.2022 a 30.11.2025)

PINA, Ana F. - Non-communicable diseases stratification and integration: a clinical approach

RODRIGUES, Cátia - Neuronal and glial growth and development: dissecting the role of RalA and exocyst in  Drosophila peripheral nervous system (2 years embargo - 09.04.2022 to 09.04.2024)

Global Public Healthcare

MARQUES, Maria - Factors influencing the quality of relationship in dementia: a mixed-methods approach (3 years embargo - 07.11.2022 a 07.11.2025)

MASTER DISSERTATIONS

Biochemistry for Health

BARATA, Isabel - The Role of Progesterone Receptor Membrane Component 1 (PGRMC1) in Cytochromes P450 (CYP)- Mediated Drug Metabolism and its Implication in Chemotherapy Resistance (2 years embargo - 06.04.2022 to 06.04.2024)

BENTO, Luís - Anti-inflammatory activity of berries driven polyphenols in zebrafish larvae fed with oxidizedlipids and LPS

COSTA, Ana - Suscetibilidade genética em doentes COVID19 hospitalizados: o caso português (2 years embargo - 05.05.2022 to 05.05.2024)

DOMINGUES, Ana - Role of micrornas in cancer drug resistance (2 years embargo - 07.02.2022 to 07.02.2024)

DUARTE, Catarina - Role of microRNAs and epigenetics modifications in paclitaxel resistance in a breast cancer cell line model (embargo 2 anos - 28.02.2022 to 28.02.2024)

VALE, Ana - Biological relevance of VUS identified in ATM gene and the role in DNA damage response (2 years embargo - 22.04.2022 to 22.04.2024)

Clinical research Magement

ABREU, Daniela - Coordenação de estudos clínicos no Centro Hospitalar de Lisboa Ocidental

BARBOSA, Ana - Relatório de estágio em coordenação de investigação clínica na Blueclinical, ltd

BARBOSA, Ana - Relatório de estágio em coordenação de investigação clínica na Blueclinical, ltd

CAETANO, Madalena - Relatório de estágio curricular em coordenação de estudos clínicos no Centro Hospitalar de Lisboa Ocidental, E.P.E.

COELHO, Carolina - Relatório de estágio em coordenação de ensaios clínicos de oncologia

CORREIA, Miguel - Estágio em coordenação de estudos clínicos na CUF Academic Center

COSTA, Mariana - Estágio de coordenação de estudos & atividades de monitorização e start-up de ensaios clínicos na AIDFM-Associação para a Investigação e Desenvolvimento da Faculdade de Medicina 

FIALHO, Helena - Estágio de monitorização de estudos na keypoint, group evidenze

GOEDE, Kay Shawnee - Estágio em gestão e monitorização de estudos clínicos na Novartis Farma

INÁCIO, Ana - Coordenação de estudos clínicos no centro hospitalar lisboa ocidental, E.P.E.

LEMOS, Beatriz - Start-up, monitorização e coordenação de estudos 

PINTO, Catarina - Relatório de estágio curricular em coordenação de estudos clínicos no Lusíadas Knowledge Center

MEDEIROS, João - Relatório de estágio de coordenação em investigação clínica em dois hospitais parceiros da Blueclinical CRP 

NETO, Pedro - Relatório de estágio em tarefas regulamentares e de monitorização na W4Research (1 year embargo - 14.12.2022 to 14.12.2023)

OLIVEIRA, Madalena - Coordenação de estudos clínicos na Blueclinical

SILVÉRIO, Catarina - Start-up e monitorização de estudos clínicos

Biomedical Research

ALMEIDA, Vicente - Regulation of γδ17 T cell homeostasis by stress-derived signals (3 years embargo - 17.11.2022 to 17.11.2025)

AMORIM, Filipa - Ovarian cancer zebrafish avatar for personalized therapy (3 years embargo - 16.11.2022 to 16.11.2025)

AMORIM, Joana - Polymeric nanoparticles for local delivery of multicolor genetic circuits in breast cancer (3 years embargo - 02.12.2022 to 02.12.2025)

ANTÓNIO, Patrícia - The effect of sphingosine-1-phosphate in lymphocytes of patients with pancreatic cancer (2 years embargo - 14.12.2022 to 14.12.2024)

CAPUCHO, Adriana - The role of carotid body in brain insulin resistance and neurodegeneration

CASTAÑEDA MATIZ, Luisamaria - Unveiling the role of DIPK2B in hematopoietic development and primary immunodeficiencies (3 years embargo - 23.11.2022 to 23.11.2025)

CATARINO, Joana - Probing striatal subpopulations in outcome-dependent action control in rats (1 year embargo - 14.02.2022 to 14.02.2023)

COELHO, Rita - Characterization of cellular organelles and the endo-lysosomal pathway in choroideremia patient cells (3 years embargo - 22.11.2022 to 22.11.2025)

COSTA, Miguel - Biological effect of Type I procollagen carboxyterminal propeptide in breast cancer tumor microenvironment (2 years embargo - 12.05.2022 to 12.05.2024)

CUNHA, César - Disclosing lysosomal dysfunction with neuronal aging : a potential mechanism of early synaptic degeneration in alzheimer's (3 years embargo - 22.03.2022 to 22.03.2025)

DIAS, Maria - Mechanisms of reinnervation during wound healing: novel roles for epithelial-glial communication (3 years embargo - 04.05.2022 to 04.05.2025)

LOPES, Francisco - Investigating the role of innate immune memory in microglial-mediated synaptic remodeling (3 years embargo - 11.05.2022 to 11.05.2025)

KAMIKI, Jéssica - Mucosal-associated invariante T cells : novel players in pancreatic cancer (2 years embargo - 18.01.2022 to 18.01.2024)

MARQUES, Ana - Contribution of high histone acetylation in memory allocation (3 years embargo - 26.04.2022 a 26.04.2025)

MOTA, Sara - A new paradigm to study NF-κB in vivo and the role of dietary phenolic metabolites using drosophila (3 years embargo - 10.05.2022 to 10.05.2025)

PACHECO, Rita - Proteomic approach to the caracterization of unknown origin male infertility

PEREIRA, Tiago - Uncovering the mechanism of CD2AP behind Alzheimer’s disease (3 years embargo - 23.11.2022 a 23.11.2025)

PIRES, Dinis - GLP1 acts on the carotid body to modulate glucose homeostasis and cardiorespiratory responses (3 years embargo - 15.12.2022 to 15.12.2025)

SAAB, Maria - Engineered cardiac tissues with improved maturation for regenerative medicine (2 years embargo - 30.11.2022 to 30.11.2024)

SILVA, Nuno - Development of zebrafish chemical screens to identify new modifiers of intestinal neutrophilic inflammation (1 year embargo - 18.02.2022 to 18.02.2023)

TEIXEIRA, Melissa - Nanoformulations of novel metal-complexes as potential antitumor agents (2 years embargo - 28.01.2022 to 28.01.2024)

Metabolism and Human Nutrition

CASTELA, Inês - Unravelling the role of adipose tissue metabolism in diet-induced weight loss : results from a randomised controlled trial (1 year embargo - 22.11.2022 to 22.11.2023)

LICKFOLD, Mafalda - Associação entre alterações da composição corporal e o perfil cardiometabólico após cirurgia metabólica e bariátrica

PITA, Débora - Portuguese questionnaires for assesing dietary supplements usage by athletes (2 years embargo - 04.04.2022 to 04.04.2024)

PROJECTO, Maria - The influence of anthocyanin treatment on the mesenteric adipose tissue expression of enampt in animal models of obesity

REMÍGIO, Inês - Associação entre o estado nutricional de indivíduos que tiveram diagnóstico de covid-19 e sintomas persistentes da doença

RODRIGUES, Tânia - The efficacy of faecal microbiota transplantation for the treatment of irritable bowel syndrome: a sistematic review and meta-analysis (1 year embargo 16.12.2022 to 16.12.2023)

SANTOS, Gilberto - Fecal samples with more bifidobacteria protect against intestinal permeability

Saúde Mental nos Cuidados Primários

MAHDY, Marwa - Assessment of Saudi public knowledge and attitudes toward mental health disorders and its demographic correlation (3 years embargo - 18.05.2022 to 18.05.2025)