Theses and Dissertations

TESES DE DOUTORAMENTO

Biomedicina

associação UAveiro

• EJTEHADIFA, Mostafa - Ubiquitin proteasome system in immune and Diffuse Large B-Cell Lymphoma (DLBCL) cancer cells (embargo 3 anos)
• REBELO, Ana - Microenvironment, the shelter of brain malignancies: bidirectional communication between glia and brain tumors (embargo 3 anos)
• VARELA, Ednilson - Determining the role of a candidate peptide hormone ligand-receptor pair during pharate adult development in Drosophila
• VITAL, Nádia - Toxicological profile of cellulose nanomaterials in human gastrointestinal cells  
• ZAHEDI, Sara - Proteomics study of malignant and non-malignant pleural effusion and their effect on healthy donor immune cells (embargo 2 anos)

Ciências da Saúde

• BARATA, Mariana - Breaking BIN1 : investigating mechanisms of synaptic dysfunction in Alzheimer’s disease (embargo 3 anos)
• BILREIRO, Carlos - Advanced diffusion-weighted imaging of the pancreas : pre-clinical and clinical developments 
• CABAÇO, Luís - Molecular mechanisms of melanosome exocytosis (embargo 3 anos)
• CABRAL, Diogo - Retinal vascular connectivity and its implications for age-related macular degeneration and retinal vascular diseases 
• CARREGOSA, Diogo - Microbiota derived metabolites from dietary phenolics and their potential to mitigate neuroinflammation (embargo 3 anos)
• DANTAS, João - Hip contact force and pressure in cam femoroaceteabular impingement syndrome 
• FERNANDEZ, Laura - Conditional survival in patients with rectal cancer managed by Watch & Wait : changing impact of risk factors over time
• FERREIRA, Marta - Concept mapping as a tool to facilitate clinical reasoning in complex multimorbidity cases in undergraduate Primary Care curricula 
• ISMAEL, Shámila - RESTART Project : an intervention study based on the microbiota and adipocyte-centric view to improve the success of bariatric surgery (embargo 3 anos)
• PIRES, Carolina - Identification of genetic variants in patients with early-onset and/or familial thyroid cancer with impact in diagnosis and treatment
• REIS, José - Immune cells inhibitory receptors and endometriosis 
• SALVADOR, Rute - Dissecting the predictive and therapeutic value of HLA-DR-expressing cytotoxic T lymphocytes in Breast Cancer
• SANTOS, Inês - Oral health care of the Portuguese elderly : influence on oral health status, self-perception, quality of life and on overall health 

especialidade Biomedicina

• FERNANDES, Andreia - Cellular and molecular mechanisms of neuronal remodelling at the neuromuscular junction (embargo 22/01/2025-22/01/2028)

Medicina

área de especialização: Investigação Clínica

• CARVALHO, Cláudia - Textbook outcome as a composite measure in gastric cancer surgery : identification of predictors of non-achievement in an international cohort  
• PAULINO, Maria - Avaliação do delirium em medicina intensiva : importância da classificação sintomática e temporal no outcome 
• VIEGAS, Alzira - Fibrinogen concentrate safety for the correction of hypofibrinogenemia on coagulopathic surgical patients 

área de especialização: Ginecologia e Obstetrícia

• QUEIRÓS, Alexandra - Placental function and obstetric outcomes in twin pregnancies : a cohort study 

Saúde Pública Global

• DESTRI, Kelli - The burden of obesity on the consumption of health services and loss of productivity in Portugal 
• GRIGAITÈ, Ugné - Responses to mental health care needs of survivors of intimate partner violence by mental health services in Lithuania and Portugal 
• PEDROSA, Bárbara - Supported accommodations for people with mental disorders in Portugal: the influence of user characteristics, care provision and contextual factors on the quality of care

DISSERTAÇÕES DE MESTRADO

Bioquímica para a Saúde

• GANÇO, Sara - Modeling the pathogenic mechanisms of metabolic dysfunction-associated steatotic liver disease (MASLD) progression using specialized human multicellular 3D organotypic models 
• REIS, Marta - Study of oxalate metabolism in a model obstructive sleep apnea (embargo 3 anos)
• VITAL, Carlos - Cardiac signaling via EVs derived from CCBE1 human cardioids in response to cardiac injury (embargo 31.01.2025 - 31.01.2028)

Gestão da Investigação Clínica (MEGIC)

associação UAveiro, ISEGI, ENSP

• BARBOSA, Manuel - Estágio em assuntos regulamentares e farmacovigilância na BlueClinical (embargo)
• COSTA, Alexandre - Relatório de estágio curricular em gestão de projeto na Blueclinical, ltd 
• DELGADINHO, Michael - Relatório de estágio curricular em gestão de projeto na Blueclinical
• DUARTE, Ana - Estágio em start-up e monitorização de investigação clínica na Evidenze Portugal
• FERREIRA, Francisca - Relatório de estágio em coordenação de estudos clínicos na unidade local de saúde Lisboa Ocidental, EPE
• PEREIRA, Ana - Relatório de estágio curricular em coordenação de estudos clínicos na Unidade Local de Saúde Lisboa Ocidental, E.P.E 
• QUINTÃOS, Raquel - Diferentes visões de um estudo clínico : relatório de estágio em coordenação, monitorização e assuntos regulamentares de estudos clínicos
• SARAIVA, Beatriz - Estágio em gestão e monitorização de estudos clínicos na CRO CETERA (embargo 31 janeiro 2025-31 janeiro 2026)
• SILVA, Ana - Internship report: curricular training at a phase i clinical trials unit 

Investigação Biomédica

• ACCIAI, Vitoria - Investigating emotion recognition in aged mice
• ANÃO, Sofia - Unveiling the links between cysteine and outcomes in peritoneal dialysis
• COLUCAS, Raquel - Striatal activity and synaptic features underlying dystonic muscle contraction
• COSTA, Marla - Functional investigation of CRISPR-Engineered synonymous DNMT3A mutations in clonal dominance of hematopoiesis
• DUARTE, Maria - How blackberry shapes mitochondrial function in obesity?  
• LONTRÃO, Mafalda - Exploring innate locomotion in Drosophila Melanogaster (embargo)
• MARINHO, Madalena - Unveiling metabolic vulnerabilities in multiple myeloma : the role of polyamines  (embargo)
• MATOS, Marta - Characterization of radioresistance mechanisms in triple negative breast cancer using the zavatar model  
• PEREIRA, Rita - Lactylation in HEPG2 toxicity response (embargo)
• PIRES, Madalena - Uncovering the role of CD9 as a new regulator of neuroinflammation after spinal cord injury (embargo)
• ROHRMOSER, Emily - Multifunctional nucleic acid-based nanoparticles for profiling breast cancer heterogeneity (embargo)
• RUIVO, Veronika - Durability of antidepressant response to ketamine: systematic review and meta-analysis (embargo)
• SANTOS, Bruna - Blinding the ear : rethinking the control for transcutaneous auricular vagus nerve stimulation 
• SANTOS, Carolina - Investigating the role of innate immunity and inflammation in the nervous system
• SLUPOWSKI, Audrey -Identification of actin-related proteins involved in oocyte meiotic spindle assembly in Drosophila Melanogaste  (embargo)
• TAVARES, Clara - Insulin-degrading enzyme as a treatment strategy for Parkinson's disease: a mouse model validation study (embargo)

Microbiologia Médica

associação IHMT, FCT, ITQB

• ALMEIDA, Raquel - Development of new class of precision antibiotics against multidrug resistant klebsiella pneumoniae 
• AMARAL, Ana - Characterization of the clonal population structure, antimicrobial resistance and virulence profile of methicillin susceptible Staphylococcus aureus from invasive infections
• ARAÚJO, Daniela - Estudo das interações Amibas / Legionella em sistemas geradores de aerossóis contaminados (embargo 3 anos)
• BARROS, Margarida - Caracterização molecular da resistência aos antimicrobianos e genotipagem de Mycoplasma genitalium em amostras positivas da área de Lisboa (embargo 3 anos)
• BENTO, MARIA - Avaliação da atividade e eficácia de fármacos propostos a reposicionamento contra Staphylococcus aureus e Staphylococcus epidermidis  (embargo 3 anos)
• CRISTÓVÃO, Inês - Otimização do protocolo de deteção do CMV em Dried blood spots em diferentes materiais (embargo 3 anos)
• DIAS, Eva - Characterization of viral-derived DNA (vDNA) forms in Hyalomma lusitanicum tick cell line in response to Hazara vírus infection
• HENRIQUES, Bruna - Genetics and cell biology of vancomycin resistance in clostridioides difficile 
• MATA, Mariana - Revisitando a infeção CMV na gravidez: de um momento imunotolerante ao momento do parto (embargo 3 anos)
• MARQUES, Débora - Identificação de inibidores de efluxo em candida albicans através de uma estratégia de reposicionamento de fármacos (embargo 3 anos)
• MARRAFA, Mário - Avaliação do padrão de suscetibilidade aos antimicrobianos e dos fatores que a influenciem em isolados ambientais de Legionella (embargo 3 anos)
• MENDES, Inês - Conhecer a epidemiologia da infeção por vírus da imunodeficiência humana tipo 2 (VIH-2) em indivíduos residentes em Portugal : o que mudou nas últimas décadas?
• QUEIRÓS, Gonçalo - Genetic diversity of the capsid protein coding region from the human immunodeficiency virus 1 (HIV-1) circulating in Angola: implications for the primary resistance to the novel capsid inhibitor Lenacapavir (embargo 2 anos)
• SIMÕES, Miguel - Unravelling the mechanism of cold-shock adaptation in the foodborne pathogen Campylobacter jejuni (embargo 3 anos)
• MARMÉ, Pedro - Vector competence of Aedes aegypti from São Tomé and Príncipe for the transmission of West Nile virus 
• VATOVA, Mariyana - Non-coding genome in bacterial virulence : characterization of regulatory rnas in listeria monocytogenes

Nutrição Humana e Metabolismo

• BARBOSA, Ana - Impact of a mediterranean-type diet on carviovascular disease risk factors : a randomized clinical trial (Greenheartediet - rate) 
• CARVALHO, Matilde - The impact of vitamin B12 on the outcome of assisted reproductive techniques: a systematic review (embargo 3 anos)
• MARISTELA, Nanque - Efeito de um extrato de amora em biomarcadores de esteatose hepática não-alcóolica num modelo de ratinho humanizado com obesidade
• MATOS, Sara - (Poly)Phenol metabolites antinflammatory role in blood-brain barrier – microglia crosstalk (embargo 3 anos)
• RODRIGUES, Joana - The effect of natural carbonated mineral water consumption in gastrointestinal transit and in gut microbiota : a randomized controlled trial (embrago 3 anos)
• SILVA, Francisco - Impact of hydration and climatic conditions on performance metrics in professional football players : an observational study 
• SUMBO, Virgínia - Caraterização do estado nutricional dos estudantes do IMNE Marista no segundo semestre do ano letivo 2023-2024

DOCTORAL THESES

Medicine

• ALMEIDA, Ana - Screening for retinopathy of prematury: how can we do better?
• BRANCO, Patrícia - Peritoneal histomorphology, biomarkers and clinical outcomes in patients with chronic kidney disease on peritoneal dialysis
• BRITO, Maria - Cervical squamous cell carcinoma (SCC) and cervical intraepithelial lesions (SILS) in hiv women: contribution of the local immune response (2 years embargo - 20.10.2023 to 20.10.2025)
• COUTO, Nuno - Tumoral exosomes profile in metastatic pancreatic adenocarcinoma patients during chemotherapy treatment
• FERNANDES, João - Social cognition in patients with schizophrenia and autism spectrum disorder
• FERREIRA, Alexandre - Improving the quality of colonoscopy
• GOUVEIA, Catarina - Osteoarticular infections in pediatric patients : changes in epidemiology and treatment (2 years embargo - 22.06.2023 to 22.06.2025)
• LUZ, José - BestFLR. Randomized controlled clinical trial comparing preoperative portal embolization with polyvinyl alcohol particles (PVA) and coils versus N-butyl cyanoacrylate (NBCA)
• MARIA, Ana - Accounting for doctors and patients perceptions in telehealth services implementation
• PARREIRA, Leonor - A novel simplified approach to radiofrequency catheter ablation of idiopathic ventricular outflow tract premature ventricular contractions: from substrate analysis to results
• RAPOSO, Luís - Intracoronary transfer of human Umbilical Cord matrix‐derived Mesenchymal Stem Cells for the preservation of left ventricular function after acute myocardial infarction: assessment of invasive hemodynamic effects and potential underlying mechanisms in a large animal pre-clinical model (1 year embargo - 02.06.2023 to 02.06.2024)
• REIS, Teresa - Prescription of benzodiazepines by primary health care doctors: characteristics of prescribing trend and implementation of an online program (2 years embargo -24.02.2023 to 24.02.2025)
• TELES, Rui - Transcatheter aortic valve implantation (TAVI) a reference model in percutaneous cardiovascular intervention

Biomedicine

• BOTA, Catarina - Testing the role of asymmetric migratory behaviors found in a novel population of mesendodermal cells (2 years embargo - 30.10.2023 to 30.10.2025)
• BURRINHA, Tatiana - Lysosome dysfunction, the link between aging and alzheimer’s disease? (3 years embargo - 27.01.2023 to 27.01.2026)
• COTOVIO, Gonçalo - Interhemispheric imbalance in mood disorders (3 years embargo - 24.01.2023 to 24.01.2026)
• CORREIA, Maria - Hydroxytyrosol and hypertension associated with chronic intermittent hypoxia: impact and contribution of AhR alternative pathway (embargo)
• DELGADO, Raquel - Regulation of survival and death pathways in chronic lymphocytic leukemia (3 years embargo - 28.06.2023 to 28.06.2026)
• FIALHO, Isabel - A psicoterapia de grupo de orientação grupanalítica: levantamento e caraterização a nível nacional, em meio hospitalar, e avaliação da eficácia em grupos psicoterapêuticos de diferentes dimensões
• QUADRADO, Carolina - Nutrient postingestive signalling : the asymmetry of the response of dopaminergic neuronal circuits (3 years embargo - 09.03.2023 to 09.03.2026)
• MADEIRA, Natália - Rethinking memory acquisition: the rules of Memory cooperation and competition (3 years embargo - 31.05.2023 to 31.05.2026)
• SOUSA, Daniela - Human Papillomaviruses in Head and Neck Squamous cell carcinomas: the relevance of HPV16 variants

Health Sciences - Biomedicine

• BRANDÃO, Duarte - A cell-type specific selection system for stem cell therapy (and other) purposes (3 years embargo - 30.05.2023 to 30.05.2026)
• FERREIRA, Andreia - Modulating membrane traffic regulators to impair breast cancer progression (3 years embargo - 13.03.2023 to 13.03.2026)

Regenerativa Medicine (ProRegeM)

• CASTANHEIRA, Pedro - The role of rab11a and rab11b in breast cancer progression (3 years embargo - 20.04.2023 to 20.04.2026)
• LOPES, João - The role of Cerl2 in cardiomyocyte differentiation and heart regeneration (3 years embargo - 11.04.2023 to 11.04.2026)
• MEYER, Catarina - The mechanism of LAMP2A-mediated exosome biogenesis and their role in intercellular communication
• MIRFAKHAR, Farzaneh - Investigating the association of endocytic trafficking regulator CD2AP gene variant K633R and the risk of developing Alzheimer's disease (3 years embargo - 01.02.2023 to 01.02.2026)
• PESTANA, Sara - Testing the role of extracellular vesicles in early left right patterning

Aging and Chronic Diseases

• KUBASOVA, Nadiya - Epigenetics and genetics of hematopoietic stem cells heterogeneity
• NETO, Matilde - Molecular mechanisms of melanin internalization and processing in keratinocytes(3 years embargo - 29.06.2023 to 29.06.2026)
• RODRIGUES, Joana - Dissecting the role of ral gtpase in neuronal and glial structure and function
• SILVA, Daniela - The role of toll-like receptors expressing t cells in autoimmunity (3 years embargo - 05.04.2023 to 05.04.2026)

MASTER DISSERTATIONS

Biochemistry for Health

• BARRADAS, Bárbara - Protein Glycosylation in Cancer Drug Resistance (3 years embargo - 15.03.2023 to 15.03.2026)
• CAÇÃO, Marta - Evaluating the protective effect of beries-derived poliphenol metabolites in mouse retina degeneration (3 years embargo - 27.03.2023 to 27.03.2026)
• CHANDE, Andreia - Alternative splicing variants in breast cancer
• CRISPIM, Daniel - The role of the cytochrome P450-enzyme complex protein factors and other oxidoreductases in the mechanisnms of acquired cancer drug resistance (2 years embargo)
• FRANCISCO, Mafalda - Phenylalanine hydroxylase (pah) enzymosomes: development of a nanosystem for enzyme substitution/replacement therapies (2 years embargo - 04.04.2023 a 04.04.2025)
• PEDRO, Margarida - Development of a screening pipeline to identify modulators of NRF2 activity (3 years embargo)
• RAMOS, Carolina - The role of extracellular vesicles in chemotherapy resistance mediated by the breast cancer-liver axis (2 years embargo)
• SALVADO, Beatriz - Beating primary ciliary dyskinesia (2 years embargo)
• SESIFREDO, Isabel - Role of lysosome exocytosis in breast cancer progression (3 years embargo)
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Clinical Research Management (MEGIC)

• AFONSO, Catarina - Coordenação de ensaios clínicos no Hospital da Luz Learning Health: relatório de estágio curricular
• COSTA, Carlota - Gestão do centro de investigação: promoção e organização de investigação interna
• EÇA, Rita - Digitalização de um centro de investigação clínica: desenho de um plano estratégico trabalho de projeto / Rita Horta Osório da Cunha de Eça 
• PICADO, Mariana - A fadiga em doentes com cancro do pulmão sob imunoterapia FADIMUN: estudo observacional prospetivo (1 year embargo)

NOVA Biomedical Research (NBR)

• ALVES, Beatriz - VIP neuroepithelial circuit in immunity and metabolism (3 years embargo)
• COELHO, Pedro - Self-paced VS cued movement initiation : characterising behaviour and underlying neural circuits (embargo)
• DAMIÃO, Catarina - Exploring neuron-glia interaction in Drosophila and human¬derived neuropsheroids
• FERRAZ, Luís - Exosomes in transcellular proteostasis and Age-Related Macular Degeneration
• FERREIRA, Bárbara - The role of glucagon : GCGR axis in pancreatic neuroendocrine
• GRENHAS, Maria - Comparative analysis of size-exclusion chromatography and ultracentrifugation for efficient isolation of extracellular vesicles in Multiple Myeloma (embargo)
• JUSTO, Inês - Exploring the role of the ESCRT-111 proteins in response to telomeric replication stress in ALT cancer cells (embargo)
• LAGOA, Filipa - The role of the immune system in MuSC aging during regeneration (embargo)
• LEÃO, José - Modulation of adenosinergic system as a therapeutic target for dysmetabolism  
• OLIVEIRA, Inês - Screening innate immunotherapy strategies in zebrafish xenograft models
• PACHECO, Maria - Developing 3D in vitro models of basal cell carcinoma (embargo)
• PEREIRA, Pedro - Extracellular vesicles : communication agents in prediabetes (1 year embargo)
• PINHO, Mariana - Dissection of glial contributions to neuronal structure and function in Drosophila melanogaster? (3 years embargo)
• QUADRADO, Carolina - Nutrient postingestive signalling: the asymmetry of the response of dopaminergic neuronal circuits
• REIS, Fábio - Epithelial to mesenchymal transition pathway in pituitary endocrine tumours
• ROSADO, Pedro - Study of the impact of the IL-7R on non-small cell lung cancer (embargo)
• SALDANHA, Inês - Extracellular Vesicles as biomarkers of hepatic metastasis in pancreatic cancer patients (embargo)

Human Nutrition and Metabolism

• BAETA, Inês - Catering for athletes: food and nutritional considerations at international athletics championships (3 years embargo - 08.11.2023 to 08.11.2026)
• CALAFATE, Catarina - Evaluation of mental health, cognitive function and quality of life of breast cancer patients and the link with gut microbiota : a preliminary study
• CAMPOS, Teresa - The link between breast cancer treatment toxicity and gut microbiota: a preliminary study (3 years embargo - 17.07.2023 to 17.07.2026)
• CAPITÃO, Carolina - The relationship between tumor metabolic activity and body composition changes in patients with cancer (3 years embargo)
• CARREIRA, Eduarda - The effects of a Mediterranean-style diet in heart disease patients running a cardiac rehabilitation program (3 years embargo - 29.11.2023 to 29.11.2026)
• FIGUEIRA, Carina - Effects of a weight loss program on cardiovascular risk in adults with obesity: the WLM3P study 
• FONSECA, Gisela - Efeito metabólico de um pequeno-almoço rápido e nutricionalmente equilibrado, desenvolvido para colmatar as necessidades da geração Y : estudo clínico aleatorizado e cruzado (1 year embargo)
• FREITAS, Mariana - O efeito de uma dieta anti-inflamatória na atividade da doença e na qualidade de vida de pacientes com artrite reumatóide: ensaio clínico randomizado controlado paralelo (1 year embargo)
• GAMA, Maria - Impact on diet quality and dietary burden of sapropterin dihydrochloride use in children with phenylketonuria : a 6 months follow-up report (embargo)
• HASSAN, Mihabd - Role of the level of micronutrients (iron, zinc and vitamin D) in developing febrile convulsion in children under six years old (3 years embargo)
• HENRIQUES, Beatriz - Impacto da ingestão de uma infusão de funcho pelas mães na cólica infantil em bebés amamentados com leite materno (2 years embargo)
• LEMOS, Maria - Urinary biomarkers of biofortified beef in healthy women explored by untargeted metabolomics
• MONTEIRO, Ana - Multiple element exposure in a population of school-aged portuguese children : from health outcomes to preventive tools (2 years embargo)
• OLIVEIRA, Sofia - Assessment of exposure to plastic aditives flame retardants in portuguese pregnant women: the role of dietary consumption and associated health effects (embargo 30.11.2023 to 30.11.2025)
• PERES, Maria - Biochemical and anthropometric outcomes of patients with paediatric heterozygous familial hypercholesterolemia after COVID-19 pandemic lockdowns (embargo 3 anos)
• PISCO, Alexandra - Effects of a weight loss program on body composition in adults with obesiy: the WLM3P study
• RELVA, Bárbara - Caracterização das alterações metabólicas que ocorrem durante uma dieta hipocalórica de 8 semanas e a sua relação com a eficiência da perda de peso
• RIBEIRO, Laila - Avaliação da exposição in utero a contaminantes ambientais em recém-nascidos prematuros
• RODRIGUES, Diana - Microspa – gut microbiota and axial spondyloarthritis: the impact on anti-tnf therapy
• SILVA, Rita - BIOMEQUIZ: validation of a food questionnaire to select stool donors (3 years embargo - 13.07.2023 to 13.07.2026)
• SOUSA, Catarina - Avaliação da exposição gestacional a metais pesados e a sua associação com o estado de saúde da mulher grávida & outcomes à nascença (2 years embargo - 22.09.2023 to 22.09.2025)
• VEIGA, Sofia - Levels of essential and toxic metals in adults with obesity undergoing a weight loss intervention: is there a link with meta-inflammation?
• VIDINHA, Duarte - The effects of a school-based intervention on the dietary quality of mid-morning snacks in second grade Azorean children

Primary Care Mental Health

• DUTRA, Filipa - Parenting styles in victims of bullying in childhood and adolescence
• RAMOS, Laura - PTSD occurrence and management strategies during the COVID-19 pandemic