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Bruno Costa-Silva

Champalimaud Foundation

Dr Costa-Silva obtained his PhD in Oncology at the Ludwig Institute for Cancer Research and AC Camargo in São Paulo, Brazil, working on pre-metastatic niche induction by tumor-derived EVs. Then he moved to Weill Cornell Medical College in New York for his post-doc at Dr. Lyden´s laboratory, where he spearheaded studies on the role of EVs in cancer pathogenesis, specifically in the metastasis of pancreatic cancer. In 2016, he relocated to Lisbon to lead the Champalimaud Foundation's Systems Oncology group. He is currently leading projects that investigate the role of extracellular vesicles in the establishment of the tumor microenvironment, with the goal of identifying plasma extracellular vesicle populations that are present in early stages of cancer and are associated with response to chemo- and immunotherapies.

 

Fun Fact:

He likes to work on "grown-up puzzles" like assembling IKEA furniture and doing minor home repairs while singing along to the greatest of all time: Francis Albert Sinatra.

  1. Couto, N., Elzanowska, J., Maia, J., Batista, S., Pereira, C.E., Beck, H.C., Carvalho, A.S., Strano Moraes, M.C., Carvalho, C., Oliveira, M., Matthiesen, R., Costa-Silva, B#. IgG+ Extracellular Vesicles Measure Therapeutic Response in Advanced Pancreatic Cancer. Cells 2022;11. Identification of a new EV biomarker to monitor therapy response in metastatic pancreatic cancer patients.
  2. Maia, J.; Otake, A.H.; Pocas, J.; Carvalho, A.S.; Beck, H.C.; Magalhaes, A.; Matthiesen, R.; Strano Moraes, M.C.; Costa-Silva, B.# Transcriptome Reprogramming of CD11b(+) Bone Marrow Cells by Pancreatic Cancer Extracellular Vesicles. Front Cell Dev Biol. 2020a;8:592518. Identification of a cancer-bone marrow communication axis mediated pancreatic cancer EVs. 
  3. Maia, J.; Batista, S.; Couto, N.; Gregorio, A.C.; Bodo, C.; Elzanowska, J.; Strano Moraes, M.C.; Costa-Silva, B.# Employing Flow Cytometry to Extracellular Vesicles Sample Microvolume Analysis and Quality Control. Front Cell Dev Biol. 2020b;8:593750. Establishment of an improved method to study EV surface proteins in native non-isolated biofluids.
  4. Hoshino, A.*, Costa-Silva, B.*, Shen, T. L.*, et al. Tumour exosome integrins determine organotropic metastasis. Nature. 2015 Nov 19;527(7578):329-35. Identification of the biological basis of the patterns of tumour EVs distribution throughout the organism and how it dictates tumour metastatic organotropism.
  5. Costa-Silva, B., Aiello, N. M., et al. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nat Cell Biol. 2015 Jun;17(6):816-26.  Identification of the mechanism, involving tumour EVs, responsible for the formation of future sites of pancreatic cancer metastasis in the liver.