Integrative Biomedicine Laboratory

Alisson M. Gontijo

Researcher Investigador Principal

PI of the Integrative Biomedicine Laboratory.

PhD in Pathology (UNESP Medical School, BR).

PD work at Institut Curie and Institute Pasteur (Paris, FR), and Instituto de Neurociencias (Alicante, ES).

Imambocus BN, Zhou F, Formozov A, Wittich A, Tenedini F, Hu C, Sauter K, Varela EM, Herédia F, Casimiro AP, Macedo A, Schlegel P, Yang C-H, Miguel-Aliaga I, Wiegert JS, Pankratz M, Gontijo AM, Cardona A, Soba P. A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae. Current Biology. CURBIO18001 In press. Preprint bioRxiv 2020.09.22.307033; doi: https://doi.org/10.1101/2020.09.22.307033.

Herédia F#, Volonté Y#, Pereirinha J#, Fernandez-Acosta M, Casimiro AP, Belém CP, Viegas F, Tanaka K, Menezes J, Arana M, Cardoso G, Macedo M, Kotowicz M, Prado Spalm F, Dibo MV, Monfardini RD, Torres TT, Mendes CS, Garelli A*, Gontijo AM*. The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction. Nature Communications. 2021 12(1):3328. # Equal contribution. * Corresponding authors.

Macedo A*, Gontijo AM*. The intersectional genetics landscape for humans. Gigascience. 2020 Aug 1;9(8):giaa083. * Corresponding authors. 

Gontijo AM*, Garelli A*. The biology and evolution of the Dilp8-Lgr3 pathway: a relaxin-like pathway coupling tissue growth and developmental timing control. Mechanisms of Development. 2018 Dec;154:44-50. doi: 10.1016/j.mod.2018.04.005. * Corresponding authors.

Garelli A*#, Heredia F#, Casimiro AP#, Macedo A, Nunes C, Garcez M, Mantas Dias AR, Volonte YA, Ulhmann T, Caparros E, Koyama T, Gontijo AM*. Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing. Nature Communications. 2015 Oct 29, 6:8732. Featured by: Pantelli K. “Sizing-up Organs”, Dec 7, 2015, BPoD, MRC UK (http://bpod.mrc.ac.uk/archive/2015/12/79), SPBD News. # Equal contributors. * Corresponding authors.

Garelli A*, Gontijo AM*, Miguela V, Caparros E, Dominguez M. Imaginal Discs Secrete Insulin-like Peptide 8 to Mediate Plasticity of Growth and Maturation. Science. 2012, 336:6081, 579-582. Evaluated 2x by Faculty of 1000: FFa 9 “Must read” & “New, Finding and Good for Teaching”. Kumar S: 2012 and Pan D & Zheng Y: 2012; Issue Highlight, Editor’s choice: VanHook AM. Sci. Signal. (2012). Perspective by I.K. Hariharan, Sci. Signal (2012). Featured in EMBO News, El Mundo, ScienceDaily etc. * Equal contribution.

Gontijo AM*, Miguela V, Whiting MF, Woodruff RC, Dominguez M.  Intron retention in the Drosophila melanogaster Rieske iron sulfur protein gene generated a new protein. Nature Communications. 2011, 2:323 doi: 10.1038/ncomms1328. * Corresponding author.

Gontijo AM, Aubert S, Roelens I, Lakowski B. Mutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegans. BMC Genetics. 2009, 10, 14.

Lopez-Rubio JJ, Gontijo AM, Nunes MC, Issar N, Hernandez Rivas R, Scherf A. 5' flanking region of var genes nucleate histone modification patterns linked to phenotypic inheritance of virulence traits in malaria parasites. Molecular Microbiology. 2007, 66, 1296-1305. Commentary in: Mol Microbiol. 2007 Dec;66(6):1291-5.

Pinhal D*, Gontijo AM*, Reyes VA, Ribeiro LR, Salvadori DM. Viable human buccal mucosa cells do not yield typical nucleoids: impacts on the single-cell gel electrophoresis/Comet assay. Environmental Molecular Mutagenesis. 2006, 47, 117-126. Erratum in: Environ Mol Mutagen. 2006, 47, 226. * Equal contribution.

Freitas-Junior LH, Hernandez-Rivas R, Ralph SA, Montiel-Condado D, Ruvalcaba-Salazar OK, Rojas-Meza AP, Mancio-Silva L, Leal-Silvestre RJ, Gontijo AM, Shorte S, Scherf A. Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites. Cell. 2005, 121, 25-36. 

De Miranda Cabral Gontijo AM*, Barreto RE*, Speit G, Valenzuela Reyes VA, Volpato GL, Favero Salvadori DM. Anesthesia of fish with benzocaine does not interfere with comet assay results. Mutation Research. 2003, 534, 165-72. * Equal contribution.

2013-18 FCT Investigator Grant (Associate Professor level), FCT (Portuguese Research Council), Portugal
2012-13 Invited Scientist Fellowship, CEDOC/FCM, Portugal
2013    Gulbenkian Training Program in Bioinformatics (GTPB) Champion, Portugal
2012    Science Without Borders “Young Talents” Program, Brazil. (declined)
2012    Canadian Developmental Biol. Conference Bursary Award (Mar 6-11, 2012)
2008-10 Marie Curie Intra-European Fellowship for Career Development, EU, Spain
2005-07 Conseil Regional d’Ile-de-France Postdoctoral Fellowship, France
2003 Student Achievement Award - US Environ. Mut. Society, declined
2002 Best Poster Award, PerkinElmer & Braz. Society of Genetics
2002 Student Achievement Award - U.S. Environ. Mut. Society
2001 Best Poster Award – Braz. Environ. Mut. Society & BB
2001 Student Travel Award & Home-stay program. IAEMS, Japan
2001-02 Direct Ph.D. Scholarship, FAPESP, BR
2001 Honor Mention & Best MSc. Dissertation Award – Braz. Soc. of Pathology