Rua Câmara Pestana 6 Edifício CEDOC II (Ed. Cinzento), Piso 1, Sala 1.17

Lara Carvalho

Investigador  Investigador Doutorado
Senior Post-Doctoral Researcher

Cell and Developmental Biologist

Main interests:

  • Epithelial repair
  • Cell adhesion and migration
  • Tissue morphogenesis
  • Mechanobiology
  • Glial biology
  • Ponte, S.; Carvalho, L., Gagliardi, M.; Campos, I., Oliveira, P.J., Jacinto, A. (2020) Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing. Biology Open bio.048629.http://dx.doi.org/10.1242/bio.048629.
  • Ponte, S., Jacinto, A., Carvalho, L.* (2019). The occluding junction protein Neurexin-IV is required for tissue integrity in the Drosophila wing disc epithelium. Matters. http://dx.doi.org/10.19185/matters.201903000014. *Corresponding author
  • Carvalho, L.*, Patrício, P., Ponte, S., Heisenberg, C. P., Almeida, L., Jacinto, A.* (2018). Occluding junctions as novel regulators of tissue mechanics during wound repair. J Cell Biol. jcb.201804048. *Corresponding authors
  • Cristo, I., Carvalho, L., Ponte, S., Jacinto, A. (2018). New role for Grainy head in the regulation of adherens junctions turnover is essential to maintain epithelial features in wound healing. J Cell Sci 131(17).
  • Carvalho, L., Jacinto, A., Matova, N. (2014) The Toll/NF-kappaB signaling pathway is required for epidermal wound repair in Drosophila. Proc Natl Acad Sci U S A. 111(50):E5373-82.
  • Geiger JA*, Carvalho L*, Campos I, Santos AC, Jacinto A (2011) Hole-in-One Mutant Phenotypes Link EGFR/ERK Signaling to Epithelial Tissue Repair in Drosophila. PLoS ONE 6(11): e28349. *Equal contribution
  • Carvalho, L. and Heisenberg, C. P. (2010). The yolk syncytial layer in early zebrafish development. Trends Cell Biol. 20,586-92.
  • Carvalho, L. and Heisenberg, C. P. (2009) Imaging zebrafish embryos by two-photon excitation time-lapse microscopy. In Methods in Molecular Biology: Humana Press. 546:273-87.
  • Carvalho, L., Stühmer, J., Kalaidzidis, Y., Bois, J., Lecaudey, V. and Heisenberg, C. P. (2009). Control of convergent yolk syncytial layer nuclear movement in zebrafish. Development 136,1305-1315.
  • Vervenne, H. B., Crombez, K. R., Lambaerts, K., Carvalho, L., Koppen, M., Heisenberg, C. P., Van de Ven, W. J. and Petit, M. M. (2008). Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extension movements during zebrafish gastrulation. Dev Biol 320, 267-77.
  • von der Hardt, S., Bakkers, J., Inbal, A., Carvalho, L., Solnica-Krezel, L., Heisenberg, C. P. and Hammerschmidt, M. (2007). The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion. Curr Biol 17, 475-87.
  • Rifes, P.*, Carvalho, L.*, Lopes, C., Andrade, R. P., Rodrigues, G., Palmeirim, I. and Thorsteinsdottir, S. (2007). Redefining the role of ectoderm in somitogenesis: a player in the formation of the fibronectin matrix of presomitic mesoderm. Development 134, 3155-65. *Equal contribution
  • Koppen, M., Fernandez, B. G., Carvalho, L., Jacinto, A. and Heisenberg, C. P. (2006). Coordinated cell-shape changes control epithelial movement in zebrafish and Drosophila. Development 133, 2671-81.
  • Link, V., Carvalho, L., Castanon, I., Stockinger, P., Shevchenko, A. and Heisenberg, C. P. (2006). Identification of regulators of germ layer morphogenesis using proteomics in zebrafish. J Cell Sci 119, 2073-83.
  • Montero, J. A., Carvalho, L., Wilsch-Brauninger, M., Kilian, B., Mustafa, C. and Heisenberg, C. P. (2005). Shield formation at the onset of zebrafish gastrulation. Development 132, 1187-98.
ORCID 0000-0001-6350-3279