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Henrique Girão

iCBR-Coimbra Institute for Clinical and Biomedical Research, Portugal

Henrique is graduated in Biochemistry and started his scientific career studying the proteolytic mechanisms in eye lens, when ubiquitin dependent lysosomal degradation was in its infancy. He has been actively involved in deciphering the mechanisms and strategies used by the cells to exchange information, particularly in the heart. Both short-range and long-distance communication have been his passion, with exosomes deserving a special place.

 

 Fun fact: Henrique is owner of a beautiful Portuguese sheepdog, his company for long daily walks, during which Henrique forgets science and enjoys listening to the last electronic music releases

  1. Martins-Marques T, Costa MC, Catarino S, Simoes I, Aasen T, Enguita FJ, Girao H. Cx43-mediated sorting of miRNAs into extracellular vesicles. EMBO Rep 2022 Jul 5;23(7):e54312.
  2.  Martins-Marques T, Ribeiro-Rodrigues T, de Jager SC, Zuzarte M, Ferreira C, Cruz P, Reis L, Baptista R, Gonçalves L, Sluijter JP, Girao H. Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes. Life Sci Alliance. 2020 ;3(12):e202000821.
  3.  Ribeiro-Rodrigues TM, Laundos TL, Pereira-Carvalho R, Batista-Almeida D, Pereira R, Coelho-Santos V, Silva AP, Fernandes R, Zuzarte M, Enguita FJ, Costa MC, Pinto-do-Ó P, Pinto MT, Gouveia P, Ferreira L, Mason JC, Pereira P, Kwak BR, Nascimento DS, Girão H. Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis. Cardiovasc Res. 2017 Sep 1;113(11):1338-1350.
  4.  Martins-Marques T, Pinho MJ, Zuzarte M, Oliveira C, Pereira P, Sluijter JP, Gomes C, Girao H. Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin. J Extracell Vesicles. 2016 Sep 29;5:32538.
  5.  Soares AR, Martins-Marques T, Ribeiro-Rodrigues T, Ferreira JV Catarino S, Pinho MJ, Zuzarte M, Anjo SI, Manadas B, Sluijter JPG, Pereira P, Girão H. Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells. Sci Rep. 2015 Aug 19;5:13243.