In my laboratory we aim to dissect how neurons and glia integrate 3D information from intrinsic and extrinsic factors to orchestrate the formation of new synaptic structures.
We use the model system Drosophila to uncover the genes and cellular mechanisms responsible for these structural and functional changes in order to understand the impact of external stimuli, such as changes in activity, in neuron and glial function.
Fernandes AR, Mendes CS, Gomes ER and Teodoro RO* (2021). Motor neurons remodel through membrane blebbing. BioRxiv. https://www.biorxiv.org/content/10.1101/2021.03.07.434250v2. * Corresponding Author
Carregosa D, Mota S, Ferreira S, Alves-Dias B, Loncarevic-Vasiljkovic N, Crespo CL, Menezes R, Teodoro RO and Nunes dos Santos C. (2021). Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms. Nutrients 2021;13::2940. http://dx.doi.org/10.3390/nu13092940.
Silva-Rodrigues JF, Patrício-Rodrigues CF, Sousa-Xavier V, Augusto PM, Fernandes AC, JP Martins, Farinho AR and Teodoro RO* (2020). Peripheral axonal ensheathing is regulated by RalA GTPase and the exocyst complex. Development Feb 4; 147(3). pii: dev174540. doi: 10.1242/dev.174540. * Corresponding Author
Patrício-Rodrigues CF and Teodoro RO*. Postsynaptic RabGTPases and Exocyst: a screen at the Drosophila neuromuscular junction. Science Matters. Jul 24th, 2018 · 10.19185/matters.201807000005. * Corresponding Author
Teodoro RO*, Pekkurnaz G, Nasser A, Higashi-Kovtun ME, Balakireva M, McLachlan IG, Camonis J and Schwarz TL* (2013). Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst. EMBO J. Jul 17, 32(14):2039-55. doi: 10.1038/emboj.2013.147.* Corresponding Authors
Murthy M*, Teodoro RO*, Miller TP, Schwarz TL (2010). Sec5, a member of the exocyst complex, mediates Drosophila embryo cellularization. Development 137(16):2773-83. doi: 10.1242/dev.048330.* Equal 1st Author Contribution.
Teodoro RO and O’Farrell PH (2003). Nitric oxide-induced suspended animation promotes survival during hypoxia. EMBO J. 22, 580-587.(Editor’s choice, Science Feb 14 2003: 979; DOI: 10.1126/science.299.5609.979a)
Awards to Neuronal Growth and Plasticity Lab Students:
2021 2nd Place Oral Presentation AIMS Research Competition (to Margarida Rafael Cruz)2019 Honor Mention Innovate Competition (iMED Conference 11.0) Poster award in basic research Astrazeneca Foundation (to Pedro Augusto)2018 Portuguese Drosophila Meeting Runner-up Talk Prize (to Joana Silva-Rodrigues)2018 Portuguese Drosophila Meeting Runner-up Poster Prize (to Andreia R. Fernandes)2017 1st prize Innovate Competition (iMED Conference 9.0) Poster award in basic research Astrazeneca Foundation (to Andreia R. Fernandes)
Awards to PI (Rita Teodoro):2018 Travel Award EMBO Workshop Neuronal Remodeling2013 FCT Investigator 20132015 MARIE SKLODOWSKA-CURIE IF 2013 Travel Grant Portuguese Neuroscience Society (SPN)2008 Postdoctoral Career Development Fellowship Harvard Medical School/Children’s Hospital Eleanor and Miles Shore for Scholars in Medicine, USA2004 Postdoctoral Fellowship Portuguese Science Foundation (FCT), Portugal1998 Doctoral Fellowship from FCT-Portugal, within the Gulbenkian PhD Program in Biology and Medicine (PGDBM)
Research carried out by several of our laboratories is supported by the LYSOCIL project and has been published in Traffic magazine.
António Jacinto (CEDOC - NMS)Cláudia Nunes Santos (CEDOC - NMS)César S. Mendes (CEDOC - NMS)Edgar Gomes (iMM - ULisboa)Ilan Davis (Oxford, UK)
NOVA Medical SchoolCampo Mártires da Pátria, 1301169-056 LisboaPORTUGAL
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