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Location

Edifício CEDOC II, Rua Câmara Pestana n.º 6
Phone: 218803127 Ext: 26048

Gabriela Araújo da Silva

Professor Professor Associado com Agregação

Bachelor's Degree in Biology and PhD in Materials Science and Technology - Biomaterials at the University of Minho, obtained in collaboration with the Universities of Pennsylvania and Thomas Jefferson in Philadelphia, USA, followed by post-doctoral studies at the University of Pennsylvania, at the Scheie Eye Institute/ FM Kirby Institute of Ophthalmology, under the guidance of Jean Bennett.

During the second year of her post-doctorate she integrates the Department of Biomedical Sciences and Medicine at the University of Algarve as Visiting Assistant Professor. The following year (2009) integrates the faculty of the same department exclusively, and starts her research group at the Center for Molecular and Structural Biomedicine (CBME) at the University of Algarve.

In 2015 joins the faculty of NOVA Medical School | Faculty of Medical Sciences, Universidade Nova de Lisboa, as an assistant professor and also its research center, CEDOC, as principal investigator.

2017-2020

  • D. M. Bitoque, S. Simao, A. V. Oliveira, S. Machado, E. Lopes, M. R. Duran, A. M. R. Costa, G. A. Silva. Efficiency of RAFT-synthesized PDMAEMA in gene transfer to the retina. Journal of Tissue Engineering and Regenerative Medicine. 2017. https://doi.org/10.1002/term.1909.
  • S. Simão, D.F. Santos, G.A. Silva. Aliskiren Decreases Oxidative Stress and Angiogenic Markers in Retinal Pigment Epithelium Cells. Angiogenesis. 2017 Feb;20(1):175-181. Doi:10.1007/s10456-016-9526-5.
  • A.V. Oliveira, A.M. Rosa da Costa, G.A. Silva. Non-viral gene strategies for ocular gene delivery. Materials Science and Engineering C. 2017. https://doi.org/10.1016/j.msec.2017.04.068.
  • R.S. Araújo, D.F. Santos, G.A.Silva. The role of the retinal pigment epithelium and Müller cells secretome in neovascular retinal pathologies. Biochimie. 2018. https://doi.org/10.1016/j.biochi.2018.06.019.
  • D.B. Bitoque, G.A. Silva. Molecular biology tools for the study and therapy of PDE6beta mutations. Journal of Biotechnology, 284, pp 1-5. https://doi.org/10.1016/j.jbiotec.2018.07.030.
  • D.B. Bitoque, A.M Rosa da Costa, G.A. Silva. Insights on the intracellular trafficking of PDMAEMA gene therapy vectors. Materials Science and Engineering C, 93, pp 277-288. https://doi.org/10.1016/j.msec.2018.07.071.
  • F. Carvalho, S.M. Calado, G.A. Silva, G.S. Diogo, J. Moreira-Silva, R.L. Reis, L. Cancela, P.J. Gavaia. Altered bone microarchitecture in a type 1 diabetes mouse model Ins2Akita. Journal of Cellular Physiology, 234(6), pp 9338-9350. https://doi.org/10.1002/jcp.27617.
  • M. Machado, G.A. Silva, D.B. Bitoque, J. Ferreira, L.A. Pinto, J. Morgado, Q. Ferreira. Self-assembled multilayer films for time-controlled ocular drug delivery. ACS Applied Bio Materials.https://doi.org/10.1021/acsabm.9b00417.
  • F. Pires, J. Santos, D.B. Bitoque, G.A. Silva, A. Marletta, V. Nunes, P. Ribeiro, J. Silva, M. Raposo. Polycaprolactone/gelatin nanofiber membranes containing EGCG loaded liposomes and their potential use for skin regeneration. ACS Applied Bio Materials. https://doi.org/10.1021/acsabm.9b00524.
  • R.S Araújo, M.S. Silva, D.F. Santos, G.A. Silva. Dysregulation of trophic factors contributes to diabetic retinopathy in the Ins2Akita mouse. Experimental Eye Research. Vol 194. May 2020, 108027. https://doi.org/10.1016/j.exer.2020.108027.
  • R.S. Araújo, G.A. Silva. PlGF silencing combined with PEDF overexpression: modeling RPE secretion as potential therapy for retinal neovascularization. Molecular Biology Reports. 47, 4413-4425. https://doi.org/10.1007/s11033-020-05496-2.
  • R.S. Araújo, D.B. Bitoque, G.A. Silva. Dual-acting antiangiogenic gene therapy reduces inflammation and regresses neovascularization in diabetic mouse retina. Molecular Therapy. 2020; 22:329.339. doi: 10.1016/j.omtn.2020.08.036.

2021

  • D.B. Bitoque*, J. Morais*, A.V. Oliveira*, S. Simão, T.M. Fortunato, S.M. Calado, R. Sequeira, A.M Rosa da Costa, G.A. Silva. Human-derived NLS enhance nonviral transfection. Bioscience Reports. 2021. 41(1). doi:10.1042/BSR20201026. *Equal contribution. 
  • R.S. Araújo, D.B. Bitoque, G.A. Silva. Development of Strategies to Modulate Gene Expression of Angiogenesis-related Molecules in the Retina. Gene 791, 145724. https://doi.org/10.1016/j.gene.2021.145724. 
  • A.C. Almeida, G.A Silva, G. Santini, M. Brízido, M. Correia, C. Coelho, L.M Borrego. Hyperglycemia is linked to Retinopathy of Prematurity. Scientific Reports 11(1), 22321. 
  • A.C. Almeida, D.B. Bitoque, M. Brízido, C. Martins, C. Coelho, L.M Borrego, G.A Silva. Serum levels of Placental Growth Factor reflect the severity of Retinopathy of Prematurity. Acta Paediatrica 110(10), 2778. 
  • D.S.M. Pereira, A.M. Pereira, T.C. Castanho, G.A. Silva, F. Falcão, P. Costa, J.M. Pêgo. Applicability and Validation of the Reaction to Tests Scale (RTT) in a sample of Portuguese medical students. BMC Psychology 9, 1, 166. 
  • D.F. Santos, M. Pais, C.S. Santos, G.A. Silva. Polyphenol metabolite pyrogallol-O-sulfate decreases microglial activation and pro-angiogenic VEGF in retinal pigment epithelium cells and diabetic mouse retina. International Journal of Molecular Sciences. Special issue on Retinal Neurodegenerative Diseases: Molecular targets driving neuroinflammation and neuroprotection. 22(21), p11402.   

2022

  • A.M.L. Oliveira, M. Machado, G.A. Silva, D.B. Bitoque, J. Ferreira, L.A. Pinto, Q. Ferreira. Graphene Oxide Thin Films with Drug Delivery Function. Nanomaterials 2022, 12(7), 1149. doi: 10.3390/nano12071149
  • D.B. Bitoque*, C. Fernandes*, A.M.L. Oliveira, G.A. Silva. Strategies to improve the  targeting of retinal cells by gene therapy vectors . Frontiers in Drug Delivery. *Equally contributing authors. doi: 10.3389/fddev.2022.899260.
  • M. Machado, A.M.L. Oliveira, G.A. Silva, D.B. Bitoque, J. Ferreira, L.A. Pinto, Q. Ferreira. Graphene biosensors - a molecular approach. Nanomaterials 2022, 12(10), 1624. doi: 10.3390/nano12101624.
  • S. Talebin, B. Mendes, J. Conniot, D.B. Bitoque, G.A.Silva, J. Conde, G.G. Wallace. Biopolymeric coatings for local release of therapeutics from biomedical implants. Advanced Science.
  • PTDC/SAU-BEB/098475/2008 - "Development of non-viral vectors for ocular gene therapy". Investigador Principal | Principal Investigator. Funding | Financiamento: 150 000 Euro. 2010-2013. Financiado pela Fundação para a Ciência e Tecnologia (FCT), Portugal.
  • PIRG05-GA-2009-249314 - Marie Curie Reintegration Grant. "EyeSee - Development of new gene therapy approaches for the treatment of ocular neovascularization", Investigador Principal | Principal Investigator. Funding | Financiamento: 100 000 Euro. 2009-2013. Financiado pela Comissão Europeia ao abrigo do programa FP7.
  • EXPL/BIM-MEC/1433/2013 - “Targeting the renin-angiotensin system for the treatment of retinal diseases“. Investigador Principal | Principal Investigator. Funding | Financiamento: 38 880 Euro. Financiado pela Fundação para a Ciência e Tecnologia (FCT), Portugal. Janeiro 2014-março 2015.
  • PTDC/BTM-ORG/28121/2017. TARGET - TArgeting diabetic Retinopathy with GEne Therapy. Role: Investigador Principal | Principal Investigator. Funding | Financiamento: 239 550€. 2018-2021. Financiado pela Fundação para a Ciência e Tecnologia (FCT), Portugal e Programa Operacional Regional de Lisboa.
  • Prémio Dr. Almeida Ruas, Melhor projecto clínico atribuído a G.A. Silva, “Analysis of the systemic levels of angiogenic and anti-angiogenic factors in diabetic retinopathy”, pela Sociedade Portuguesa de Diabetologia. 2020. 5000 Euro.
  • EXPL/BTM-ORG/0500/2021. RBPinG. Exploring the therapeutic potential of RBP3 in retinal gene therapy. 49994 €. Investigador Principal | Principal Investigator. Funding | Financiamento: 49994€. 2022-2024. Financiado pela Fundação para a Ciência e Tecnologia (FCT).
  • ORCID: 0000-0001-5946-1918
  • Ciência ID: DC1E-F164-FDD9