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Campo Mártires da Pátria, 130 1169-056 Lisboa, Portugal

Sérgio Laranjo

Professor Professor Auxiliar
Principal Investigator; Academic Director of the Knowledge Center in AI, RWE & Digital Health; and Deputy Director of the D³@NOVA

Sérgio Laranjo is a Consultant Paediatric Cardiologist and Assistant Professor at NOVA Medical School, dedicated to transforming cardiovascular medicine through artificial intelligence, computational methods, and digital health innovation. His clinical and academic work focuses on improving diagnostic precision and therapeutic outcomes across diverse patient populations, with particular expertise in cardiac arrhythmias, autonomic dysfunction, and pediatric cardiology.

At Santa Marta's Hospital, ULS São José, he leads specialized clinical services including the Paediatric Clinical Arrhythmology Section, the Cardiac Rehabilitation Programme, and the Syncope Unit.

At NOVA Medical School, he is also the Academic Director of the AI, Real-World Evidence & Digital Health Knowledge Centre, and Deputy Director of the Digital Data Design Institute (D³@NOVA). His research program integrates artificial intelligence for cardiovascular diagnostics, computational cardiology and advanced modeling, electrocardiographic imaging (ECGi), digital twins for personalized medicine, and signal processing methodologies for autonomic assessment. He is committed to ethical and responsible AI implementation, addressing algorithmic bias, ensuring transparency, and prioritizing clinical utility through rigorous validation and human-computer interface design.

His work translates technological innovations from research concepts into clinical reality, with measurable impact on patient outcomes. He has authored over 60 peer-reviewed publications and received multiple national and international awards. Additionaly, he is a Fellow of the European Society of Cardiology (FESC) and the American College of Cardiology (FACC), he serves on the board of the AEPC Working Group on Genetics, Basic Science and Myocardial Disease, and represents the National Reference Centre for Congenital Heart Disease in the ERN GUARD-Heart network.

Core Specialties: Paediatric Cardiology | Cardiac Electrophysiology | Arrhythmias | Artificial Intelligence in Healthcare | Computational Cardiology | Digital Health | Digital Twins | Autonomic Physiology | Electrocardiographic Imaging | Real-World Evidence | Syncope

2025:
  • Laranjo S, Fonseca H, Felix AC, Gourine A, Pinto F, Oliveira M, Rocha I. Haemodynamic Patterns in Reflex Syncope: Insights from Head-Up Tilt Tests in Adults and Children. J Clin Med. 2025;14(6):1874. doi: 10.3390/jcm14061874
  • Ferreira M, Geraldes V, Felix AC, Oliveira M, Laranjo S, Rocha I. Advancing Atrial Fibrillation Research: The Role of Animal Models, Emerging Technologies and Translational Challenges. Biomedicines. 2025;13(2):307. doi: 10.3390/biomedicines13020307
  • Cardoso I, Nunes S, Brás P, Viegas JM, Marques Antunes M, Ferreira A, Almeida I, Custódio I, Trigo C, Laranjo S, Graça R, Cruz Ferreira R, Oliveira M, Aguiar Rosa S, Antunes D. The contribution of genetics to the understanding and management of cardiomyopathies: Part 1. Rev Port Cardiol. 2025;44(4):245-254. doi: 10.1016/j.repc.2024.03.007
  • Melo X, Lopes A, Coelho R, Simão B, Oliveira I, Marôco JL, Laranjo S, Fernhall B, Santa-Clara H. Acute effects of commercial group exercise classes on arterial stiffness and cardiovagal modulation in healthy young and middle-aged adults: A crossover randomized trial. PLoS One. 2025;20(3):e0319130. doi: 10.1371/journal.pone.0319130
  • Cardoso I, Melo M, Brás P, Miguel Viegas J, Almeida I, Nunes S, Custódio I, Trigo C, Laranjo S, Graça R, Ferreira RC, Oliveira M, Rosa SA, Antunes D. The contribution of genetics to the understanding and management of cardiomyopathies: Part 2. Rev Port Cardiol. 2025:S0870-2551(25)00096-4. doi: 10.1016/j.repc.2025.02.006
2024:
  • Silva Cunha P, Laranjo S, Monteiro S, Almeida IG, Mendonça T, Fontes I, Ferreira RC, Almeida AG, Didenko M, Oliveira MM. Left Atrial Wall Thickness Estimated by Cardiac CT: Implications for Catheter Ablation of Atrial Fibrillation. J Clin Med. 2024;13(18):5379. doi: 10.3390/jcm13185379
  • Silva Cunha P, Laranjo S, Monteiro S, Portugal G, Guerra C, Rocha AC, Pereira M, Ferreira RC, Heijman J, Oliveira MM. The impact of atrial voltage and conduction velocity phenotypes on atrial fibrillation recurrence. Front Cardiovasc Med. 2024;11:1427841. doi: 10.3389/fcvm.2024.1427841
  • Ferreira M, Cunha PS, Felix AC, Fonseca H, Oliveira M, Laranjo S, Rocha I. AFTER-CA: Autonomic Function Transformation and Evaluation Following Catheter Ablation in Atrial Fibrillation. J Clin Med. 2024;13(19):5796. doi: 10.3390/jcm13195796
  • Ferreira M, Oliveira M, Laranjo S, Rocha I. Linking Sleep Disorders to Atrial Fibrillation: Pathways, Risks, and Treatment Implications. Biology. 2024;13(10):761. doi: 10.3390/biology13100761
  • Ven LV, Félix AC, Suarez J, Rodrigues B, Dias J, Pinto FF, Laranjo S. The Effect of Cardiac Rehabilitation in Paediatric Fontan Circulation Patients: A Prospective Intervention Study. Medicina (Kaunas). 2024;60(10):1566. doi: 10.3390/medicina60101566
  • Ven LV, Félix AC, Suarez J, Dias J, Pinto FF, Laranjo S. Cardiac Rehabilitation for Fontan Circulation Patients: A Systematic Review, and Meta-Analysis. Medicina (Kaunas). 2024;60(11):1817. doi: 10.3390/medicina60111817
  • Constante AD, Suarez J, Lourenço G, Portugal G, Cunha PS, Oliveira MM, Trigo C, Pinto FF, Laranjo S. Prevalence, management, and outcomes of atrial fibrillation in paediatric patients: insights from a tertiary cardiology centre. Medicina (Kaunas). 2024;60(9):1505. doi: 10.3390/medicina60091505
  • Marôco JL, Arrais I, Silvestre T, Pinto M, Laranjo S, Magalhães J, Santa-Clara H, Fernhall B, Melo X. Post-acute exercise cardiovagal modulation in older male adults with and without type 2 diabetes. Eur J Appl Physiol. 2024;124(5):1475-1486. doi: 10.1007/s00421-023-05386-0
  • Brás PG, Cunha PS, Timóteo AT, Portugal G, Galrinho A, Laranjo S, Oliveira M. Evaluation of left atrial strain imaging and integrated backscatter as predictors of recurrence in patients with paroxysmal, persistent, and long-standing persistent atrial fibrillation. J Interv Cardiac Electrophysiol. 2024;67(3):479-492. doi: 10.1007/s10840-023-01654-y
  • Teixeira BL, Cunha P, Jacinto AS, Portugal G, Laranjo S, Valente B, Oliveira M. Epicardial adipose tissue volume assessed by cardiac CT as a predictor of atrial fibrillation recurrence following catheter ablation. Clin Imaging. 2024;110:110170. doi: 10.1016/j.clinimag.2024.110170
  • Afonso C, Mendes DA, Queirós RV, Serra CM, Laranjo S. Long QT syndrome: LQT3 variant presenting in a bradycardic newborn. Cureus. 2024;16(12):e76430. doi: 10.7759/cureus.76430
  • Cardoso I, Cunha PS, Laranjo S, Grazina A, Viegas JM, Portugal G, Valente B, Lousinha A, Brás P, Brás M, Ferreira RC, Oliveira M. Validation of a Heart Failure Risk Score in a Cohort of Cardiac Resynchronization Therapy Patients Under Remote Monitoring: Results from the TriageHF™ Algorithm. J Innov Card Rhythm Manag. 2023;14(9):5576-5581. doi: 10.19102/icrm.2023.14093
2023:
  • Ferreira M, Laranjo S, Cunha P, Geraldes V, Oliveira M, Rocha I. Orthostatic Stress and Baroreflex Sensitivity: A Window into Autonomic Dysfunction in Lone Paroxysmal Atrial Fibrillation. J Clin Med. 2023;12(18):5857. doi: 10.3390/jcm12185857
  • Geraldes V, Laranjo S, Nunes C, Rocha I. Central Autonomic Network Regions and Hypertension: Unveiling Sympathetic Activation and Genetic Therapeutic Perspectives. Biology (Basel). 2023;12(8):1153. doi: 10.3390/biology12081153
  • Silva Cunha P, Antunes DO, Laranjo S, Coutinho A, Abecasis J, Oliveira MM. Case report: Mutation in NPPA gene as a cause of fibrotic atrial myopathy. Front Cardiovasc Med. 2023;10:1149717. doi: 10.3389/fcvm.2023.1149717
  • Silva Cunha P, Fonseca P, Laranjo S, Montenegro Sá F, Tereno Valente B, Portugal G, Gonçalves H, Nogueira da Silva M, Brandão L, Martins Oliveira M, Primo J. Clinical outcome of a single procedure cryoballoon ablation for the treatment of atrial fibrillation: A real-world multicenter experience in Portugal. Rev Port Cardiol. 2023;42(4):363-370. doi: 10.1016/j.repc.2022.06.008
  • Gomes SA, Laranjo S, Trigo C, Pinto FF. The TANGO2 disease and the therapeutic challenge of acute arrhythmia management: a case report. Eur Heart J Case Rep. 2023;7(2):ytad044. doi: 10.1093/ehjcr/ytad044
  • Silva Cunha P, Teixeira BL, Laranjo S, Portugal G, Valente B, Delgado AS, Pereira M, Rocha AC, Brás M, Cruz MC, Paulo M, Lousinha A, Guerra C, Ferreira RC, Oliveira MM. A simplified single transseptal puncture approach using high-density 3D voltage mapping for atrial fibrillation ablation: acute complications and long-term results. Front Cardiovasc Med. 2023;10:1309900. doi: 10.3389/fcvm.2023.1309900
2022:
  • Silva Cunha P, Portugal G, Laranjo S, Alves M, Luísa Papoila A, Valente B, Sofia Delgado A, Lousinha A, Paulo M, Brás M, Guerra C, Cruz Ferreira R, Martins Oliveira M. The atrial fibrillation burden during the blanking period is predictive of time to recurrence after catheter ablation. Int J Cardiol Heart Vasc. 2022;43:101138. doi: 10.1016/j.ijcha.2022.101138
  • Marôco JL, Pinto M, Laranjo S, Santa-Clara H, Fernhall B, Melo X. Cardiovagal Modulation in Young and Older Male Adults Following Acute Aerobic Exercise. Int J Sports Med. 2022;43(11):931-940. doi: 10.1055/a-1826-6267
  • Cunha PS, Laranjo S, Heijman J, Oliveira MM. The Atrium in Atrial Fibrillation - A Clinical Review on How to Manage Atrial Fibrotic Substrates. Front Cardiovasc Med. 2022;9:879984. doi: 10.3389/fcvm.2022.879984
  • Hormigo I, Milheiro Silva T, Laranjo S, Trigo C, Garcia AM, Gouveia C, Brito MJ. Protocol-based cardiotoxicity monitoring in hydroxychloroquine medicated COVID-19 pediatric patients. Rev Port Cardiol. 2022;41(2):155-163. doi: 10.1016/j.repc.2021.02.017
2021:
  • Riccio J, Alcaine A, Rocher S, Martinez-Mateu L, Laranjo S, Saiz J, Laguna P, Martínez JP. Characterization of Atrial Propagation Patterns and Fibrotic Substrate With a Modified Omnipolar Electrogram Strategy in Multi-Electrode Arrays. Front Physiol. 2021;12:674223. doi: 10.3389/fphys.2021.674223
  • Cunha PS, Laranjo S, Lourenço A, Rodrigues L, Cardoso I, Portugal G, Valente B, Delgado AS, Ferreira RC, Abreu A, Oliveira MM. Lockdown measures for COVID-19 outbreak and variation in physical activity in patients with heart failure and cardiac implantable devices. Int J Cardiol Heart Vasc. 2021;37:100906. doi: 10.1016/j.ijcha.2021.100906
  • Best Work on Electrophysiology, ARRITMIAS 2024 (Oliveira M, Cunha P, Laranjo S, Monteiro S, Portugal G, Rocha AC, Pereira M, Guerra C, Ferreira RC, Heijman J) – Recognition for research on atrial fibrillation phenotypes using voltage and conduction velocity mapping
  • Winner "Mais Valor em Saúde – Vidas que Valem" Programme, 2021 (Value-Based Healthcare category) – Award for MORE-CARD project on remote monitoring in heart failure prevention (coordinated by Prof. Mário Oliveira, co-developed by Dr Sérgio Laranjo)
  • Fellow of the American College of Cardiology (FACC), 2020
  • Fellow of the European Society of Cardiology (FESC), 2020
  • Jorge Quininha Prize, Portuguese Society of Cardiology, 2016 – Baroreflex effectiveness index in cardiac resynchronization therapy candidates (Laranjo S, Serôdio J, et al.)
  • Jorge Quininha Prize, Portuguese Society of Cardiology, 2012 (Tilt training) – Tilt training increases vasoconstrictor reserve in neurocardiogenic syncope (Laranjo S, Oliveira M, et al.)
  • Jorge Quininha Prize, Portuguese Society of Cardiology, 2012 (AF modulation) – Vagal modulation and atrial fibrillation vulnerability (Oliveira M, Laranjo S, et al.)
  • Jorge Quininha Prize, Portuguese Society of Cardiology, 2011 – Acute vagal modulation of electrophysiology (Oliveira M, Laranjo S, et al.)
  • Jorge Quininha Prize, Portuguese Society of Cardiology, 2010 (two awards) – Effects of vagal stimulation on AF initiation and termination (Oliveira M, Laranjo S, et al.)
  • Young Award Prize – Basic Research, Portuguese Society of Cardiology, 2015 – Electromagnetic impedance tomography system for cardiac electrical activity mapping (Laranjo S, Gil B, et al.)
  • Young Award Prize – Clinical Research, Portuguese Society of Cardiology, 2014 – Multivariate autonomic and baroreflex model in reflex syncope prediction (Laranjo S, Tavares C, et al.)
  • Young Award Prize – Basic Research, Portuguese Society of Cardiology, 2013 – Prevalence and morphological properties of anatomical isthmuses in tetralogy of Fallot (Laranjo S, Kapel G, et al.)
  • FUNDAÇÃO ALTRAN Prize – Technological Innovation & Telemedicine, 2014 – IBiCardioRotors prototype for non-invasive atrial fibrillation mapping (Laranjo S as co-developer)
  • Best Publication Revista Portuguesa de Cardiologia, 2012 – Electrophysiological modulation of atria and pulmonary veins (Oliveira M, Laranjo S, et al.)
  • Best Oral Communication, Portuguese Society of Cardiology, 2010 – Tilt training increases vasoconstrictor reserve (Laranjo S, Oliveira M, et al.)
  • Lisbon Arrhythmia Meeting Best Communication, 2011 – Connexin and ion channel remodeling (Oliveira M, Laranjo S, et al.)
  • Lisbon Arrhythmia Meeting Best Communication, 2010 – Gap junctional remodeling induced by atrial pacing (Oliveira M, Laranjo S, et al.)
  • EFNS/EFAS Investigator Award, 2008 (Madrid) – Wavelet analysis of heart rate and blood pressure variability in atrial fibrillation (Oliveira M, Laranjo S, et al.)
  • Honourable Mention, ARRITMIAS 2016 – Long-term follow-up of ICD in congenital heart disease (Monteiro A, Cunha PS, Oliveira M, Laranjo S, et al.)
  • Honourable Mention, ARRITMIAS 2014 – Autonomic-induced atrial remodeling mechanisms (Oliveira M, Laranjo S, et al.)
  • Honourable Mention, ARRITMIAS 2013 – A2A receptors in atrial fibrillation (Oliveira M, Laranjo S, et al.)
  • Annual International Medical Students Meeting Prize, 2014 – Arterial baroreflex function in heart failure (Serôdio J, Laranjo S, et al.)
  • 1st Prize Imaging Clinical Case, Joint Annual Meeting SPC, 2017 – Uhl's disease case (Rito T, António M, Laranjo S, et al.)